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Heart OMics in AGEing

Objective

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing HF before the onset of symptoms and ii. subsets of patients who are more likely to respond to specifically targeted therapies (personalized medicine). In available cohorts, we will identify the most promising ‘omics-based BM profiles for the pre-symptomatic diagnosis and future prediction of HF in patients at risk. The predictive value of the BMs for other co-morbidities commonly associated with HF and ageing will also be investigated. Furthermore, in a prospective trial, we will investigate the potential for targeting preventive therapy at patients with the greatest likelihood of response and the lowest risk of adverse effects. Our selection of innovative ‘omics-based BMs is based on knowledge of biological pathways of the disease, which may facilitate identification of ‘Biotargets’ for future therapies. On the economic side, HOMAGE will act as an economic catalyst for European SMEs in the field of cardiovascular and ageing BMs, estimated to peak annual turnovers of up to 800 M€.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 717 205,45
Administrative Contact
Marie-Ange Luc (Mrs.)

Participants (21)

INSERM TRANSFERT SA
France
EU contribution
€ 450 000
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patricia Joseph-Mathieu (Ms.)
FONDATION TRANSPLANTATION
France
EU contribution
€ 750 000
Address
Rue De La Brot 4
21850 St Apollinaire
Activity type
Research Organisations
Administrative Contact
Stéphanie Grojean (Dr.)
ACS BIOMARKER BV
Netherlands
EU contribution
€ 2 274 400
Address
Oxfordlaan 70
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heico Breek (Mr.)
Randox Clinics Limited
United Kingdom
EU contribution
€ 672 000
Address
Diamond Road 34
BT29 4QY Crumlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Cartwright (Mr.)
MEDIZINISCHE UNIVERSITAT GRAZ

Participation ended

Austria
EU contribution
€ 19 574,47
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Burkert Pieske (Prof.)
THE UNIVERSITY OF MANCHESTER

Participation ended

United Kingdom
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 310 000
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
Administrative Contact
Andrew Solomon (Dr.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 547 553,95
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
UNIVERSITY OF HULL
United Kingdom
EU contribution
€ 725 600
Address
Cottingham Road
HU6 7RX Hull
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Neil Scott (Mr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 925 000
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Van Der Zander (Mr.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 200 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 400 000
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 825 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 300 000
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Robinson (Mr.)
EMORY UNIVERSITY NON PROFIT CORP

Participation ended

United States
EU contribution
€ 40 566,49
Address
Clifton Road, Ne, 4Th Floor 1599
30322 Atlanta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javed Butler (Prof.)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 150 000
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 700 000
Address
Rotenburger Strasse 20
30659 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Harald Mischak (Prof.)
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
United States
EU contribution
€ 159 433,51
Address
State Street 35
12201 Albany Ny
Activity type
Other
Administrative Contact
Alina Stroia (Ms.)
UNIVERSITY OF KEELE ROYAL CHARTER
United Kingdom
EU contribution
€ 310 000,05
Address
Keele University Finance Dpt
ST5 5BG Keele
Activity type
Higher or Secondary Education Establishments
Administrative Contact
James Allman (Mr.)
TATAA BIOCENTER AB
Sweden
EU contribution
€ 195 256,80
Address
Odinsgatan 28
411 03 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anne Hansen (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 328 409,28
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martina Eickmann (Mrs.)