Objetivo "Eukaryotic organisms have the ability to defend themselves against pathogenic microorganisms through the action of pattern recognition receptors (PRRs) perceiving specific pathogen-associated molecular patterns (PAMPs), what activates a range of fast, efficient and multi-layered defense responses leading to PAMP-triggered immunity (PTI), also named basal immunity. To counteract this defense strategy, successful pathogens deploy effectors proteins, the primary function of which is to evade/interfere with PTI.In both plants and animals, extensive attention has been paid over the years to the identification of PRRs, signalling components, pathogens effectors and their host targets, in order to dissect the molecular dialog between hosts and pathogens (including bacteria, fungi and viruses). Strikingly, no information related to basal immunity against plant viruses has been obtained so far, in spite of many converging elements suggesting that basal immunity against viruses also exists in plants.The project IBIS aims at the identification of the cellular processes underlying basal immunity against plant viruses, using the Arabidopsis thaliana - Plum pox virus (PPV) pathosystem as a model for plant-virus interactions.Via holistic and multidisciplinary approaches (combining molecular biology, virology, biochemistry, cellular biology, reverse genetics, transcriptomics and proteomics), I will make use of the knowledge I acquired on both basal immunity signaling and plant virology as entry points to tackle the three project objectives: I will first characterize cellular components involved in basal immunity against PPV through a candidate approach and transcriptomic analyses. In addition, I will identify PPV-encoded proteins acting as viral effectors suppressing basal immunity as well as their cellular targets. Finally, I will address the question of the possible overlap between basal immunity pathways triggered by different classes of plant pathogenic microbes." Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesmicrobiologymycologynatural sciencescomputer and information sciencesartificial intelligencepattern recognitionnatural sciencesbiological sciencesmolecular biology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2012-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Aportación de la UE € 194 046,60 Dirección 147 RUE DE L'UNIVERSITE 75007 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Fabienne Schneider (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
