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Bioanalytical evaluation, identification, and characterisation of disinfection by-products formed during drinking water treatment

Bioanalytical evaluation, identification, and characterisation of disinfection by-products formed during drinking water treatment

Objective

Drinking water disinfection, mandatory to provide drinking water free of pathogens, is associated with the formation of disinfection by-products (DBPs) that have been linked to public health concerns. Drinking water chlorination produces a wide range of toxic DBPs, only a fraction of which have been identified let alone characterised for their toxic potential. Bioanalytical tools should complement chemical analysis for a comprehensive risk assessment to assure that unidentified DBPs are also captured. In vitro bioassays will enable the detection of mixture effects caused by known and unknown transformation products. However, many DBPs are volatile and polar and thus cannot be evaluated with current methods. After implementation and validation of improved extraction and dosing techniques, my goal in the proposed project is to develop a screening tool that combines cell based bioassays indicative of relevant human health endpoints with chemical analysis to identify toxicologically relevant DBPs. The combination of bioanalytical assessment with sophisticated state-of-the-art chemical analysis will provide a guidance scheme for an effect directed identification of toxicologically relevant transformation products formed during advanced water treatment processes. This aims not exclusively at single compounds but also at substance groups or toxicophores. The establishment of applicable bio-analytical screening tools will enable the toxicological monitoring of advanced treated waters and allow the evaluation of pre- and post-treatments for by-product mitigation.
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Coordinator

EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ

Address

Uberlandstrasse 133
8600 Dubendorf

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 261 401,70

Administrative Contact

Laura Klein (Ms.)

Project information

Grant agreement ID: 329169

Status

Closed project

  • Start date

    1 August 2013

  • End date

    31 July 2016

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 261 401,70

  • EU contribution

    € 261 401,70

Coordinated by:

EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ

Switzerland