Obiettivo Even at their earliest stages, human cancers are more than just cells with malignant potential. Cells and extracellular matrix components that normally support and protect the body are coerced into a tumour microenvironment that is central to disease progression. My hypothesis is that recent advances in tissue engineering, biomechanics and stem cell biology make it possible to engineer, for the first time, a complex 3D human tumour microenvironment in which individual cell lineages of malignant, haemopoietic and mesenchymal origin will communicate, evolve and grow in vitro. The ultimate aim is to build this cancerous tissue with autologous cells: there is an urgent need for models in which we can study the interaction of human immune cells with malignant cells from the same individual in an appropriate 3D biomechanical microenvironment.To achieve the objectives of the CANBUILD project, I have assembled a multi-disciplinary team of collaborators with international standing in tumour microenvironment research, cancer treatment, tissue engineering, mechanobiology, stem cell research and 3D computer-assisted imaging.The goal is to recreate the microenvironment of high-grade serous ovarian cancer metastases in the omentum. This is a major clinical problem, my lab has extensive knowledge of this microenvironment and we have already established simple 3D models of these metastases.The research plan involves:Deconstruction of this specific tumour microenvironmentConstruction of artificial scaffold, optimising growth of cell lineages, assembly of the modelComparison to fresh tissueInvestigating the role of individual cell lineagesTesting therapies that target the tumour microenvironmentMy vision is that this project will revolutionise the practice of human malignant cell research, replacing misleading systems based on cancer cell monoculture on plastic surfaces and allowing us to better test new treatments that target the human tumour microenvironment. Campo scientifico natural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncology Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-AG-LS4 - ERC Advanced Grant - Physiology, Pathophysiology and Endocrinology Invito a presentare proposte ERC-2012-ADG_20120314 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-AG - ERC Advanced Grant Istituzione ospitante QUEEN MARY UNIVERSITY OF LONDON Contributo UE € 2 431 035,00 Indirizzo 327 MILE END ROAD E1 4NS London Regno Unito Mostra sulla mappa Regione London Inner London — East Tower Hamlets Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Catherine Cowton (Ms.) Ricercatore principale Frances Rosemary Balkwill (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto QUEEN MARY UNIVERSITY OF LONDON Regno Unito Contributo UE € 2 431 035,00 Indirizzo 327 MILE END ROAD E1 4NS London Mostra sulla mappa Regione London Inner London — East Tower Hamlets Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Catherine Cowton (Ms.) Ricercatore principale Frances Rosemary Balkwill (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato