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A progress of tuberculosis and HIV/tuberculosis treatment assessed by fingerprinting of small molecule-biomarkers in patients from Eastern Europe

Objective

A dramatically high incidence of multidrug-resistant (MDR) and extended drug resistant (XDR) tuberculosis (TB) was reported in WHO European Region. Countries in Eastern Europe still fail to control TB and in, for example, Ukraine, a number of new TB cases is as high as 100-299 per 100 000 (data for 2010). TB is often accompanied by HIV on this territory. In EU countries, patients with MDR and XDR-TB recover with the efficiency of only 32%. For successful control of TB, quick diagnosis is among most important factors. In low-income countries, TB diagnostics is restricted mainly to clinical manifestations and sputum smear microscopy. TB clinical symptoms are often obscured in HIV positive individuals and sputum smear test detects only up to 60% of TB cases. Modern more efficient methods are not affordable. Furthermore, there are few tools to judge the efficiency of a certain therapy in already confirmed TB cases. We hypothesize that cheaper and quicker detection of TB is possible as well as assessment of the treatment progress over the time. It could be done through measurement of small molecule biomarkers in body fluids of the patients. A network has been created between Umea University, Sweden, Metchnikov’s University/TB Clinics, Ukraine and University Hospital Germans Trias i Pujol, Spain that has access to a modern metabolomics facility and an extensive work experience with TB and chemical analysis of biomedical samples. We propose to collect samples from Ukrainian TB and HIV/TB patients under treatment and analyze them with several chromatographic methods in order to detect relevant biomarkers. We plan also to genotype M.tuberculosis isolates from these patients, monitor possible antibiotic resistance development and evaluate the host response. An array of these methods will help to get a detailed and dynamic clinical description of the cases and assign certain small molecules levels to respective events during treatment of TB, MDR-TB and HIV/TB co-infection.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

FP7-PEOPLE-2012-IRSES
See other projects for this call

Funding Scheme

MC-IRSES - International research staff exchange scheme (IRSES)

Coordinator

UMEA UNIVERSITET
Address
Universitetomradet
901 87 Umea
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 87 400
Administrative Contact
Olena Rzhepishevska (Dr.)

Participants (1)

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 45 600
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Administrative Contact
Cristina Prat-Aymerich (Dr.)