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Tissue Specific Delivery via Cleavable and Degradable Polymers

Objective

The host group (Professor Bradley of the University of Edinburgh) has worked in the area of polymer chemistry for a large number of years in several different areas, specifically: (i). The development of polymeric microspheres and their application in the cellular delivery of a variety of cargos and (ii). The discovery of polymeric substrates, surfaces and gels that control cellular function. The basis of my proposal is to synergistically combine these two areas of research expertise and generate a family of totally novel new materials with a rich biomedical potential. Concretely the two research areas (i) and (ii) will be brought together but with an added twist – specifically the project will target the generation of polymers and linkers designed to be cleaved or fragmented in the proximity of diseased tissues, cancers or regions of high oxidative stress. The nature of the environment will subsequently trigger the delivery of a cargo; entrapped within the polymer or attached to the linker; into cells or tissues at specific sites of infection, injury or disease, thereby allowing the control or modulation of specific biomedical processes.
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Coordinator

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
Eh8 9yl Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 221 606,40

Administrative Contact

Angela Noble (Ms.)

Project information

Grant agreement ID: 327903

Status

Closed project

  • Start date

    1 July 2013

  • End date

    30 June 2015

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 221 606,40

  • EU contribution

    € 221 606,40

Coordinated by:

THE UNIVERSITY OF EDINBURGH

United Kingdom