Objective Patients with high-risk hematological tumors can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). However, the main causes of failure of HSCT are infections, tumor relapse and over-shooting immune responses of the donor T cells to healthy cells and tissues of the patient or graft-versus host disease (GvHD). Therefore, this treatment is still associated with a high morbidity and mortality, as well as a high economic burden. Our previous EU FP6 project, ALLOSTEM, resulted in a number of achievements, including a ‘first in man’ clinical trial that used a highly innovative novel cell selection strategy (Streptamer technology) for the generation of non-ATMP (advanced therapy medicinal product) monovirus specific T cell products. Continuing from ALLOSTEM, we now aim to develop two novel Streptamer-based clinical cell selection processes and its corresponding cell products. A multispecific T cell product targeting several viruses and tumors as well as a primary regulatory T cell product targeting GvHD will be developed to market maturity. These two cell products will improve the outcome of allogeneic HSCT. A significant improvement in the outcome and this coupled with a significant reduction of the costs for a large number of patients in Europe will further broaden the application in other forms of cancer of this curative treatment. In order to achieve this goal we assembled a consortium led by the University Hospital of Würzburg with Prof. Einsele as scientific coordinator together with renowned clinical scientists in the field of HSCT (all key players in ALLOSTEM). Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineemergency medicinegraft versus host diseasemedical and health sciencesclinical medicinetransplantation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Call for proposal FP7-HEALTH-2013-INNOVATION-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT EU contribution € 1 118 101,00 Address JOSEF-SCHNEIDER-STRASSE 2 97080 Wurzburg Germany See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Anne Von Thun (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ANTHONY NOLAN United Kingdom EU contribution € 925 266,00 Address AGINCOURT ROAD 75-87 UNITS 2-3 HEATHGATE PLACE NW3 2NU LONDON See on map Activity type Research Organisations Administrative Contact Alejandro Madrigal (Prof.) Links Contact the organisation Opens in new window Total cost No data JUNO THERAPEUTICS GMBH Germany EU contribution € 2 531 268,00 Address RUDOLF-WISSELL-STRASS 28 37079 GOETTINGEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lothar Germeroth (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 935 110,00 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Frederik Falkenburg (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 115 766,00 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 57 025,00 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Dietz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data