Obiettivo Accurate diagnosis of malaria is essential to timely install proper treatment. Current diagnostic methods for malaria have limitations, such as detection limit and problems with antigen persistence after successful treatment (rapid diagnostic tests) or may require technical expertise and equipment (microscopy). Treatment on the basis of clinical symptoms only (fever = malaria) must be abandoned.Molecular diagnostic tests (MDx) could circumvent some of the mentioned limitations, but tests are incompatable with the Point of Care concept as they require sample processing, have a contamination risk and complicated read-out systems. Although Real-Time PCR assays have overcome some of these problems, the need of large and expensive equipment and the inability to perform it directly on blood shows the need to further improvement and simplification of MDx.Building on the successful outcomes of EU FP7 project “MALACTRES”, the current proposal aims to further built on the concept of a direct on blood PCR system combined with a simple read-out system. This concept has the following advantages:- Direct on blood: no DNA extraction or sample processing;- Simple read-out system (black/white), no need for gel electrophoresis or computer.The proof of concept was delivered in laboratory ring trials and field evaluations in Thailand and Burkina Faso. The proposed diagnostic will have the following additional features:- Direct on blood and simple read-out- Closed system: reduced risk of contamination- Stabilizing reagents included: increased shelf life, no cold storage- Cheap, quick, sensitive and specific.It is envisaged that a full marketable product will be available in 36 months. During development the consortium (dominated by SMEs) will also look into possibilities to adapt the developed system to small hand-held PCR devices preferably in combination with solar-power operated or chargeable batteries that further enhances the application of the test in remote settings. Campo scientifico medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesopticsmicroscopynatural scienceschemical scienceselectrochemistryelectrophoresis Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-2 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Contributo UE € 318 255,26 Indirizzo MEIBERGDREEF 15 1105AZ Amsterdam Paesi Bassi Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Gulseren Yalvac (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FORSITE DIAGNOSTICS LTD Regno Unito Contributo UE € 534 274,00 Indirizzo BLOCK 21, Sand Hutton YO41 1LZ YORK Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Paul Meakin (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Q-BIOANALYTIC GMBH Germania Contributo UE € 677 080,00 Indirizzo FISCHKAI 1 27572 BREMERHAVEN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Boris Oberheitmann (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato GINOLIS OY Finlandia Contributo UE € 498 700,00 Indirizzo AUTOMAATIOTIE 1 90460 Oulunsalo Mostra sulla mappa Regione Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Sinikka Fabritius (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato HET KONINKLIJK INSTITUUT VOOR DE TROPEN Partecipazione conclusa Paesi Bassi Contributo UE € 624 064,74 Indirizzo MAURITSKADE 63 1092 AD Amsterdam Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Research Organisations Contatto amministrativo Hendricus Schallig (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato