Control of Programmed Cell Death by Metacaspases in plants

Projektinformationen

PLANTPCDCONTROL

ID Finanzhilfevereinbarung: 331392

Abgeschlossenes Projekt

Startdatum 23 Mai 2014

Enddatum 15 November 2016

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 223 002,20

EU-Beitrag € 223 002,20

Koordiniert durch

CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB
Spain

Ziel

Plant pathogens devastate crops resulting in yield losses and increasing the use of often unsustainable pesticides. Understanding the basic mechanisms of the plant immune system will increase our ability to successfully combat plant diseases, satisfying the growing needs for sustainable food production, a future challenge for European agriculture.
Cell death has a central role in innate immune responses in both animals and plants. The hypersensitive response (HR) is a plant-specific form of programmed cell death (PCD) occurring at the site of attempted pathogen invasion. A tight regulation of HR is essential in order to avoid unnecessary tissue damage beyond the infection site. However, the signaling pathways leading to HR still remain ill-defined. We have recently shown that Arabidopsis metacaspases, distant homologs of animal caspases, antagonistically control pathogen-triggered HR. However, their precise mode of action, regulation and substrates remain largely unknown. With this project we will use a combination of proteomic, genetic, cell biology and biochemical approaches to dissect the mechanisms underlying PCD control by this family of proteins. Defining the first plant deathosome will be a major breakthrough in plant sciences, moving forward with knowledge that can be directly translated into agronomically relevant species.
We will use a multidisciplinary approach, benefitting from transnational collaborations already established by the candidate with research groups located in Europe and the USA. A Marie Curie International Incoming Fellowship will ensure the continuity of the candidate’s high-impact research at the host institution, an emerging reference center for plant sciences in Spain. Reintegration of the candidate will complement and synergize with the expertise of the host, directly contributing to European excellence.

Wissenschaftliches Gebiet

• agricultural sciences › agriculture, forestry, and fisheries › agriculture › sustainable agriculture
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › cell biology
• natural sciences › biological sciences › botany

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB

Kontakt Verwaltung

Juan Antonio Bermejo (Mr.)

• EU-Beitrag: € 223 002,20
• Adresse: PARC DE RECERCA DE L UAB CAMPUS UAB EDIFICI CRAG BELLATERRA ; 08193 Cerdanyola Del Valles ; Spanien
• Region: Este › Cataluña › Barcelona
• Aktivitätstyp: Other
• Gesamtkosten: Keine Daten