Objective Cancer is a major scientific and economical challenge that our society has to face and new therapeutic approaches should now be evaluated in order to decrease human and financial cost of this disease. After suffering from many drawbacks, cancer immunotherapy, which aims at mobilizing the immune system to fight cancer, has recently gained enthusiasm with the completion of several randomized phase III clinical trials. Because of their ability to trigger the innate immune responses, ligands for pattern-recognition receptors (PRRs) have been included in several vaccination protocols. These approaches, however, have unveiled new hurdles. Here we propose to investigate a new approach for cancer immunotherapy in Human, based on the use of PRR ligand-containing tumor cells. We have recently shown that introducing the bacterial protein flagellin into tumor cells stimulates innate immune cells and induces a tumor-specific adaptive immunity. Flagellin recognition by myeloid cells engages three distinct PRRs, but subsequent molecular mechanisms controlling presentation of tumor-associated antigens to T lymphocytes are still poorly defined. In addition, the precise nature of adaptive immune responses that efficiently eradicate tumor cells still needs to be precisely characterized before developing pre-clinical trials in Humans. In this context, flagellin-expressing tumor cells represent a powerful tool to uncover fundamental questions on the control of the adaptive immunity by the innate immune system, which will be necessary for the development of new anti-tumor immunotherapies. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2012-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) EU contribution € 100 000,00 Address CALLE MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Garcia Luzma (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
