Obiettivo Many childhood brain tumour patients currently have low prognosis. The introduction and combination of new non-invasive MRI techniques to investigate tumour micro-environment may hold the key to increasing the accuracy of determining prognosis and treatment response. Diffusion weighted magnetic resonance imaging (DWI) provides information on the cellularity of tissue based on the mean apparent diffusion coefficient (ADC), and this has been used to describe tumour tissue structure. More recently the mean ADC has been shown to be the combination of different components, fast and slow, and these components may give more insight into tissue structure than ADC alone. Magnetic Resonance Spectroscopy (MRS) provides information of metabolites within the tissue, and metabolite profiles have been shown to be a strong characteristic of brain tumour type. However MRS can also be used to probe tissue micro-environment, such as temperature, and this provides another means of investigating tumours. The relative change in metabolite concentrations over different MRS echo times can be used to measure the relaxation properties (T2) and which are dependent upon molecular environment. The combination of these measurements to provide increased prognosis accuracy and measure treatment response will be investigated. The combination of MRS and DWI for diagnosis potential has been investigated, however using micro-environmental probes, diffusion components, temperature and T2 relaxation, is novel and will provide vital information gained non-invasively, which will potentially change patient treatment and outcomes. The study proposed aims to assess the tumour micro-environment thoroughly through MRS and DWI. Campo scientifico engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingnatural sciencesphysical sciencesopticsspectroscopy Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2012-IIF - Marie Curie Action: "International Incoming Fellowships" Invito a presentare proposte FP7-PEOPLE-2012-IIF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IIF - International Incoming Fellowships (IIF) Coordinatore THE UNIVERSITY OF BIRMINGHAM Contributo UE € 231 283,20 Indirizzo Edgbaston B15 2TT Birmingham Regno Unito Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo May Chung (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato