Obiettivo Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives. Campo scientifico medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologyimplantsengineering and technologymedical engineeringdiagnostic imagingmedical and health sciencesbasic medicineneurologyengineering and technologymaterials engineeringnanocomposites Programma(i) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Argomento(i) NMP.2013.2.2-2 - Biomaterials: Imaging and rapid precise prototyping technology for custom made scaffolds Invito a presentare proposte FP7-NMP-2013-EU-China Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE Contributo UE € 486 600,00 Indirizzo VIA BONOMEA 265 34136 Trieste Italia Mostra sulla mappa Regione Nord-Est Friuli-Venezia Giulia Trieste Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Gabriele Rizzetto (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italia Contributo UE € 353 310,00 Indirizzo VIA MOREGO 30 16163 Genova Mostra sulla mappa Regione Nord-Ovest Liguria Genova Tipo di attività Research Organisations Contatto amministrativo Claudia Schiaffino (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI TRIESTE Italia Contributo UE € 150 000,00 Indirizzo PIAZZALE EUROPA 1 34127 Trieste Mostra sulla mappa Regione Nord-Est Friuli-Venezia Giulia Trieste Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paolo Balsini (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOLE NORMALE SUPERIEURE Francia Contributo UE € 404 880,00 Indirizzo 45, RUE D'ULM 75230 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Anne Cormier (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MAX IV Laboratory, Lund University Svezia Contributo UE € 404 998,00 Indirizzo Paradisgatan 5c 22100 LUND Mostra sulla mappa Regione Södra Sverige Sydsverige Skåne län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Jens Schouenborg (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato