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Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders

Objective

Brain disorders comprise a major burden for the society. Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases. The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics. Furthermore, recent studies have shown that proteolytic activity may release from the ECM/CAMs cryptic ligand(s) that activate cell surface receptors and initiate intracellular signalling cascade(s). Thus, ECM and its enzymatic modifications have emerged as a highly topical research area, also because their extracellular localization makes the development of enzymatic inhibitors more feasible. This proposal brings together a group of well-established academic and industrial partners sharing interest in the ECM and its proteolysis. In the proposal there is clearly an overlapping interest in specific brain conditions and structures to be investigated, making the consortium ideally suited to provide a comprehensive picture for the role of ECM proteolysis in brain function and dysfunctions. While the academic partners focus on specific research questions, the industrial members are to provide the entire consortium with high-throughput techniques and powerful research tools. This combination of conceptual scientific vision, tools and approaches should be of great benefit for the young researchers to be trained. The trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training program is on expanding knowledge and on developing new treatments to anxiety disorders, schizophrenia, mental retardation and Alzheimer’s. A unifying neurobiological concept in the consorted effort to tackle these conditions is the involvement of abnormal synaptic plasticity.

Field of science

  • /medical and health sciences/clinical medicine/psychiatry/schizophrenia
  • /medical and health sciences/clinical medicine/psychiatry/anxiety disorders
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Poland
Activity type
Research Organisations
EU contribution
€ 764 262,18
Administrative Contact
Marta Rucinska (Mrs.)

Participants (8)

DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
EU contribution
€ 669 506,64
Address
Sigmund Freud Strasse 27
53127 Bonn
Activity type
Research Organisations
Administrative Contact
Anette Schoen (Ms)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 573 413,28
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Ms.)
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
EU contribution
€ 375 657,48
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Administrative Contact
Dorothy Searles (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 225 368,88
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Dagmar Lange
University College London
United Kingdom
EU contribution
€ 250 652,16
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kamila Kolasinska (Ms.)
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 255 948,66
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Cormier (Ms)
STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA
Portugal
EU contribution
€ 206 481
Address
Rua Dos Inventores S/n Edificio Madan Parque Salas 2.18 E 2.19
2825 182 Caparica
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nancy Lopes (Mrs.)
EVOTEC AG*
Germany
EU contribution
€ 190 800,72
Address
Essener Bogen 7
22419 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ken Young (Mr.)