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Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease

Objective

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical research. This educational scope is placed in the context of a significant research objective: to improve quality of life of patients with chronic kidney disease (CKD) and diminish the severe health and economic burden imposed by this disease, by providing better diagnostic and prognostic means. Established CKD has been selected based on the accumulation of existing molecular data, and complementarity to active European programs focusing on early stage CKD in the context of diabetes and hypertension, in which participants of the consortium are actively involved. The main objectives of iMODE-CKD are:
- Training young scientists to become the next generation of true translational multidisciplinary researchers exploiting multiple -omics technologies to their full extent.
- Training young scientists in Systems Biology approaches to decipher molecular pathology and understanding clinical phenotypes.
- Identifying and validating molecules involved in progression of renal complications trough clinical –omics in established CKD.
- Understanding the molecular determinants of established CKD through integrative Systems Biology.
iMODE-CKD provides the opportunity to train young researchers not only in the different fields of -omics research, but also in -omics data evaluation, combining of datasets from different -omics traits, and exploiting both, data and literature, to enable the generation of in silico models of the molecular pathology of specific diseases. Such approaches will also enable development of new and specific drugs; and pave the road towards stratified/personalized medicine.
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Coordinator

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON

Address

Soranou Efesiou 4
115 27 Athina

Greece

Activity type

Research Organisations

EU Contribution

€ 746 065,62

Administrative Contact

Dimitris Raptis (Mr.)

Participants (10)

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 255 948,66

MOSAIQUES DIAGNOSTICS GMBH

Germany

EU Contribution

€ 418 369,60

Ss. CYRIL AND METHODIUS UNIVERSITY IN SKOPJE

North Macedonia

EU Contribution

€ 167 511,30

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 285 056,64

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Italy

EU Contribution

€ 240 837,96

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 222 068,88

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 30 842,90

GENOMIC INVESTMENTS BV

Netherlands

EU Contribution

€ 78 953,82

UNIVERSITAETSKLINIKUM AACHEN

Germany

EU Contribution

€ 191 225,98

GenomeScan B.V.

Netherlands

EU Contribution

€ 157 907,64

Project information

Grant agreement ID: 608332

Status

Closed project

  • Start date

    1 September 2013

  • End date

    31 August 2017

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 2 794 789

  • EU contribution

    € 2 794 789

Coordinated by:

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON

Greece