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NANOCARRIERS FOR THE DELIVERY OF ANTIMICROBIAL AGENTS TO FIGHT RESISTANCE MECHANISMS

Objective

The worldwide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive. Novel therapeutic approaches are urgently required to deliver the well-documented existing drugs in an optimized fashion to: i) protect them toward degradation; ii) increase their bioavailability; iii) reduce toxic side effects; iv) increase patient compliance and iv) reduce treatment duration and related costs. In this sense, nanocarriers based on cyclodextrins (CDs) are particularly appealing for the delivery of antibiotics. This approach is of main interest for tuberculosis (TB), infections related to Salmonella Typhimurium, Staphyloccocus aureus and for species most frequently implicated in hospital infections such as enteric gram-negative rods. We will design and characterize CD-based nanocarriers, test their ability to encapsulate drugs, study their efficacy in vitro on bacteria and infected cells. The best formulation will be tested in vivo and scaled up. The objectives of the CycloN Hit project are to take full advantage of nanotechnology and of the high level interdisciplinary expertise of the partners to efficiently encapsulate and protect antibiotics in nanocarriers to combat resistant bacteria, and study the mechanisms in biological systems using state-of-the art techniques. This will be accomplished through a strong and demanding training program for 11 Early Stage and 5 young Experienced Researchers which will gather interdisciplinary expertise of 11 Full partners and 6 Associated partners, of which 7 are SMEs. Using the most recent advances in the nanomedicine field, the final goal of the CycloN Hit project is to bring to the preclinical studies an antibiotic formulation for the treatment of TB and more tailored alternative therapeutic approaches for other resistant microorganisms.

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 1 259 170
Administrative Contact
Véronique Debisschop (Ms.)

Participants (10)

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""
Greece
EU contribution
€ 366 969,24
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
Administrative Contact
Euripides Papadopoulos (Mr.)
UNIVERSIDAD DE CASTILLA - LA MANCHA
Spain
EU contribution
€ 234 931,62
Address
Calle Altagracia 50
13071 Ciudad Real
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Llanos Carrión Varela (Ms.)
UNIVERSIDAD DE ALMERIA
Spain
EU contribution
€ 234 931,62
Address
Carretera Sacramento Canada
04120 Almeria
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antonio Miguel Posadas Chinchilla (Prof.)
UNIVERSITA DEGLI STUDI DI CATANIA
Italy
EU contribution
€ 382 894,98
Address
Piazza Universita 2
95131 Catania
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annamaria Resi (Dr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 249 087,96
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Ilse Gert Julia Manet (Dr.)
HASKOLI ISLANDS
Iceland
EU contribution
€ 230 637
Address
Saemundargotu 2
101 Reykjavik
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsteinn Loftsson (Prof.)
HELLENIC PASTEUR INSTITUTE
Greece
EU contribution
€ 230 318,88
Address
Vassilissis Sofias Avenue 127
11521 Athens
Activity type
Research Organisations
Administrative Contact
Vivi Miriagou (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 268 175,16
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Annika Bergman (Dr.)
CYCLOLAB CIKLODEXTRIN KUTATO-FEJLES
Hungary
EU contribution
€ 205 505,52
Address
Illatos 7
1097 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Fenyvesi (Dr.)
NANOLOGICA AB
Sweden
EU contribution
€ 232 272,04
Address
Drottning Kristinas Väg 45
114 28 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberto Hanoi Labrador (Mr.)