Objectif Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding - known as ‘tick immunity’ - or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens (TBPs). Also humans with hypersensitivity to tick-bites have a lower risk of contracting tick-borne diseases (TBDs). Therefore, anti-tick vaccines encompass an innovative strategy to prevent TBDs in humans, or animals and wildlife to indirectly reduce the risk of contracting TBDs for humans.Overall Objective To identify and characterize tick proteins involved in ‘tick immunity’ and TBP transmission and to use this knowledge to develop anti-tick vaccines to prevent multiple human TBDs.Methods Using state of the art proteomic and transcriptomic approaches we will identify and characterize novel tick salivary gland proteins, which will be subsequently assessed as anti-tick vaccines to protect against LB, babesiosis and TBE in animal models. In addition, through an integrated and multidisciplinary approach involving CEE public health institutes, health organizations and industrial companies we will examine how to develop anti-tick vaccines and implement these in public health systems.Impact ANTIDotE will deliver 1) essential knowledge on the biological mechanisms involved in the pathogenesis of TBDs, 2) proof of concept of an anti-tick vaccine protecting against multiple human TBPs and 3) plans for exploitation and implementation of anti-tick vaccines, significantly contributing to downscaling the severe medical and economic burden that TBDs have on societies. Champ scientifique medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2013.2.3.4-1 - Neglected infectious diseases of Central and Eastern Europe Appel à propositions FP7-HEALTH-2013-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Contribution de l’UE € 988 320,00 Adresse MEIBERGDREEF 15 1105AZ Amsterdam Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Higher or Secondary Education Establishments Contact administratif Frank Groen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire VIROLOGICKY USTAV SLOVENSKEJ AKADEMIE VIED Participation terminée Slovaquie Contribution de l’UE Aucune donnée Adresse Dubravska Cesta 9 84505 BRATISLAVA Voir sur la carte Type d’activité Research Organisations Contact administratif Hana Krasoňová (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BIOLOGICKE CENTRUM AKADEMIE VID CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Tchéquie Contribution de l’UE € 565 900,00 Adresse BRANISOVSKA 1160/31 370 05 Ceske Budejovice Voir sur la carte Région Česko Jihozápad Jihočeský kraj Type d’activité Research Organisations Contact administratif Zdenka Grufikova (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FREIE UNIVERSITAET BERLIN Allemagne Contribution de l’UE € 466 100,00 Adresse KAISERSWERTHER STRASSE 16-18 14195 Berlin Voir sur la carte Région Berlin Berlin Berlin Type d’activité Higher or Secondary Education Establishments Contact administratif Annegret Körner (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Espagne Contribution de l’UE € 373 400,00 Adresse PARQUE TECNOLOGICO EDIFICIO 801 A 48160 Derio Vizcaya Voir sur la carte Région Noreste País Vasco Bizkaia Type d’activité Research Organisations Contact administratif Alfonso Egaña (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GENXPRO GMBH Allemagne Contribution de l’UE € 208 700,00 Adresse ALTENHOFTER ALLEE 3 60438 Frankfurt Voir sur la carte Région Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Cornelia Lenhart (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Pays-Bas Contribution de l’UE € 141 445,00 Adresse Antonie Van Leeuwenhoeklaan 9 3721 MA Bilthoven Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Research Organisations Contact administratif Marjon Hartwigsen (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED, VEREJNA VYSKUMNA INSTITUCIA Slovaquie Contribution de l’UE € 255 920,00 Adresse DUBRAVSKA CESTA 9 845 05 Bratislava Voir sur la carte Région Slovensko Bratislavský kraj Bratislavský kraj Type d’activité Research Organisations Contact administratif Hana Krasoňová (Ms.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée