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Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors

Objective

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million received radiotherapy. In the long-term, potentially 20% of those suffering with mild to severe side-effects (~1.4 million) might benefit from alleviation of symptoms, with resulting reductions in the cost of care in the EU.
REQUITE aims to develop validated clinical models and incorporate biomarkers to identify before treatment cancer patients at risk of side-effects and use the models to design interventional trials aimed at reducing side-effects and improving QoL in cancer survivors who underwent radiotherapy.
REQUITE will:
1. carry out a multi-centre, longitudinal, observational study to collect standardised data and samples in breast, prostate and lung cancer patients;
2. validate biomarkers with published evidence of predictive value;
3. replicate published clinical models and incorporate replicated biomarkers to create validated predictive algorithms;
4. use the prospectively validated models and biomarkers to design interventional trial protocols aiming to reduce side-effects and improve QoL in high-risk patients.
REQUITE builds on collaborations with a proven history of data sharing, enlarged to a consortium with expertise in patient recruitment, knowledge management, biomarker testing and predictive model development. SME involvement for biomarker assays will facilitate future clinical implementation and commercial exploitation. The outcome of this project will be validated predictive models for three common cancers and trial protocols using the models to investigate interventions aimed at reducing long-term side-effects and improving the QoL of cancer survivors.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /humanities/history and archaeology/history
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
M13 9PL Manchester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 959 166,26
Administrative Contact
Claire Faichnie (Ms.)

Participants (15)

UNIVERSITE MONTPELLIER I.

Participation ended

France
Address
Bd Henri Iv,5
34060 Montpellier
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Guillaumon (Mrs.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 737 782,50
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Ina Wiest (Dr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 506 305,20
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms.)
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 931 631
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Adams (Mrs.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 600 728,04
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Myriam Witvrouw (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 66 592
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
UNIVERSITE DE MONTPELLIER
France
EU contribution
€ 119 307,60
Address
163 Rue Auguste Broussonnet
34090 Montpellier
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Guillaumon (Mrs.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 187 088,80
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
Administrative Contact
Antonio Cannarozzo (Dr.)
FUNDACION PUBLICA GALEGA DE MEDICINA XENOMICA
Spain
EU contribution
€ 304 240
Address
Hospital Clínico Universitario. Edif. Consultas Planta -2. Choupana S/n
15706 Santiago De Compostela
Activity type
Research Organisations
Administrative Contact
Ana Ezara Trillo (Ms.)
THE CHRISTIE NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 189 652
Address
Wilmslow Road 1
M20 4BX Manchester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Sally Smillie (Ms.)
Source Bioscience plc
United Kingdom
EU contribution
€ 634 720
Address
Orchard Place, Business Park 1
NG8 6PX Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nick Cox (Mr.)
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 84 015
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barry Rosenstein (Prof.)
STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Netherlands
EU contribution
€ 237 800
Address
Dr. Tanslaan 12
6229 ET Maastricht
Activity type
Research Organisations
Administrative Contact
Floor Franssen (Ms.)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 123 840
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anke Keller (Mrs.)
INSTITUT REGIONAL DU CANCER DE MONTPELLIER
France
EU contribution
€ 314 539,60
Address
Rue De La Croix Verte 31 Parc Euromedecine
34090 Montpellier
Activity type
Research Organisations
Administrative Contact
Nathalie Coux (Mrs.)