Obiettivo Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for inflammatory liver conditions such as primary sclerosing cholangitis (PSC). Mesenchymal Stromal Cells (MSC) are a mixed population of plastic-adherent (PA) cells isolated from bone marrow, umbilical cord and adipose tissue. Preclinical studies show that intravenous administration of PA-MSC reduces liver inflammation/damage, however only one MSC-based clinical study has been reported to date.MERLIN will examine if MSC can safely reduce biliary damage in mouse models followed by a clinical study in patients with PSC. We have identified an antibody (S2) that isolates comparable MSC from human & mouse marrow, enabling testing of pure functionally distinct cell S2+ & S2- and PA-MSC populations. We will use the world’s first GMP-compliant non-bead-based cell sorter to select S2+ MSC to comply with future therapeutic regulatory requirements. MERLIN partners will use novel methods to enhance MSC efficacy in PSC - by reducing immune clearance of MSC & by promoting MSC functionality & localisation in vivo.We will assess if MSC sub-sets exert differing levels of control upon liver inflammation in pre-clinical models, as well as defining their proliferation and mechanism of action. We will develop entirely novel biomarkers for PSC within the disease pathway pre and post cell infusion. The optimal combination of MSC sub-set and “efficacy enhancement”, will be selected for progression to a Phase 2 clinical safety study in patients with PSC.MERLIN will deliver a comprehensive data-set on optimised purified MSC and their efficacy/safety in pre-clinical models prior to a clinical trial in patients with PSC. Campo scientifico social sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinehepatology Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.1.4-1 - Controlling differentiation and proliferation in human stem cells intended for therapeutic use Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore THE UNIVERSITY OF BIRMINGHAM Contributo UE € 1 624 439,00 Indirizzo Edgbaston B15 2TT Birmingham Regno Unito Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo May Chung (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ORBSEN THERAPEUTICS LIMITED Irlanda Contributo UE € 931 516,00 Indirizzo UNIT 1 GALWAY BUSINESS PARK H91 Galway Mostra sulla mappa Regione Ireland Eastern and Midland Dublin Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Stephen Elliman (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Paesi Bassi Contributo UE € 732 850,00 Indirizzo DR MOLEWATERPLEIN 40 3015 GD Rotterdam Mostra sulla mappa Regione West-Nederland Zuid-Holland Groot-Rijnmond Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Carla Baan (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Partecipazione conclusa Regno Unito Contributo UE Nessun dato Indirizzo TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Renata Schaeffer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FONDAZIONE HUMANITAS PER LA RICERCA Partecipazione conclusa Italia Contributo UE € 165 644,16 Indirizzo Via Manzoni 20089 Rozzano Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Danilo Petroni (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOINVISION INC Stati Uniti Contributo UE € 549 031,00 Indirizzo BETA DRIVE 781 STE E 44143 MAYFIELD VILLAGE OH Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Debashish Roy (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato NHS BLOOD AND TRANSPLANT Regno Unito Contributo UE € 682 172,00 Indirizzo OAK HOUSE REEDS CRESCENT WD24 4QN Watford Mostra sulla mappa Regione East of England Bedfordshire and Hertfordshire Hertfordshire Tipo di attività Research Organisations Contatto amministrativo Daniel Hollyman (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato PINTAIL LTD Irlanda Contributo UE € 327 200,00 Indirizzo SPRINGHILL AVENUE 77 A94 K542 Blackrock Mostra sulla mappa Regione Ireland Eastern and Midland Dublin Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ciaran Clissmann (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PADOVA Italia Contributo UE € 370 105,84 Indirizzo VIA 8 FEBBRAIO 2 35122 Padova Mostra sulla mappa Regione Nord-Est Veneto Padova Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Luisa Caldon (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
