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New approaches in the development of Hypoallergenic implant material in Orthopaedics: steps to personalised medicine

Objective

Europe is confronted by a demographic challenge as a decreasing work force has to support an increasing elderly population. The economic risk implied by this burden could be addressed by efforts to achieve an increase in Healthy Life Years. One key element would be to ensure unrestricted mobility for especially the elderly, allowing them to stay at work for longer. Irreversible joint deterioration often requires a joint replacement. Implantation of artificial joints is one of the most successful orthopaedic interventions. However, an increasing number of patients receive revision surgery with these 10 % of these contract an infection and 50 % develop an adverse immune reaction (AIR) to conventional implant material. At the moment the reasons for the development of AIR are inadequately understood. Our proposal contains innovative solutions concerning this problem. A predictive approach using biomarkers will identify patients with risk to develop AIR. These patients will receive hypoallergenic endoprostheses, avoiding AIR to conventional material. Novel hypoallergenic material combinations will be developed in the frame of this consortium by material scientists and implant manufacturer. Via immunological, microbiological and biocompatibility testing the development and production process will be improved constantly. The matching of implant material with the allergenic background of patients will avoid complicated and cost-intensive reverse reactions and is a step towards personalised medicine. A further approach is to achieve a better understanding of mechanisms of AIR, and its faster and easier diagnosis using sensitive diagnostic biomarkers for an accurate differentiation from low-grade infection. Additionally, mathematical modelling of results from different methods will show us the gene regulatory network that leads to an amplification of the adverse immune response triggered by prosthetic implants and will develop predictive models of AIR process.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Address
Universitaetsplatz 2
39106 Magdeburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 372 151
Administrative Contact
Sigmar Beust (Mr.)

Participants (9)

TARTU ULIKOOL
Estonia
EU contribution
€ 900 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aare Märtson (Dr.)
SIEC BADAWCZA LUKASIEWICZ - INSTYTUT OBROBKI PLASTYCZNEJ
Poland
EU contribution
€ 404 291
Address
Jana Pawla Ii 14
61 139 Poznan
Activity type
Research Organisations
Administrative Contact
Joanna Bednarczyk (Mrs.)
TERMESZETTUDOMANYI KUTATOKOZPONT

Participation ended

Hungary
EU contribution
€ 117 143
Address
Magyar Tudosok Korutja 2
1117 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katalin Balázsi (Dr.)
TEKNOLOGISK INSTITUT
Denmark
EU contribution
€ 431 376
Address
Gregersensvej 1
2630 Taastrup
Activity type
Research Organisations
Administrative Contact
Mikael Poulsen (Dr.)
PROGENIKA BIOPHARMA SA
Spain
EU contribution
€ 750 928
Address
Parque Ibaizabal Bidea Edificio 504 Parque Tecnologico Derio
48160 Vizcaya Bizkaia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sergio Escorza (Dr.)
MATHYS AG BETTLACH
Switzerland
EU contribution
€ 455 199
Address
Robert Mathys Strasse 5
2544 Bettlach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Delfosse (Dr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 104 223
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
ENERGIATUDOMANYI KUTATOKOZPONT
Hungary
EU contribution
€ 472 856
Address
Konkoly Thege Miklos Ut 29-33
1121 Budapest
Activity type
Research Organisations
Administrative Contact
Krisztina Szakolczai (Dr.)
ARTTIC
France
EU contribution
€ 274 433
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)