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Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease

Objective

Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing EU population. The Euroclast consortium (7 academic, 2 private and 1 ass. partner) focuses on osteoclast heterogeneity, a recent insight that poses new fundamental questions best tackled by a multi-partner consortium capable of assembling the sophisticated molecular, genetic and imaging tools required. We will analyze changes in gene and protein expression during osteoclast (trans)differentiation from different precursor cell pools and in various bone sites and relate this to osteoclast activity and sensitivity to therapeutics. The osteoclast resorptive
apparatus will be studied using in depth and will define the key enzymatic and molecular machinery to be translated into novel site-specific drug targets or biomarkers. High throughput screening assays for therapeutics and ELISAs for biomarkers will be developed with our private partners. Our multidisciplinary and cross-sectorial approach will improve understanding and treatment of common disorders associated with osteoclast malfunction and train 11 early stage researchers (ESRs) in modern cell and bone biology. We will provide extensive training in generic skills and all ESRs will spend time with our private partners and be seconded to other academic partners to ensure they are well equipped for employment in research and industrial settings. Euroclast will produce an on-line repository for osteoclast protocols, make methodological and scientific advances in osteoclast and bone biology and create a sustainable network of ESRs and senior academics to tackle diseases of bone loss into the future.

Field of science

  • /social sciences/economics and business/business and management/employment

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 746 011,42

Participants (9)

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 604 213,28
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 227 568,88
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 265 425,16
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 265 425,16
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 227 568,88
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
TURUN YLIOPISTO
Finland
EU contribution
€ 266 697,64
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S
Denmark
EU contribution
€ 290 079,46
Address
Herlev Hovedgade 207
2730 Helev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE DIAGNOSTICS BV

Participation ended

Netherlands
Address
Nieuweweg 279
6603 BN Wijchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUTURE DIAGNOSTICS SOLUTIONS BV
Netherlands
EU contribution
€ 242 361,46
Address
Nieuweweg 279
6603 BN Wijchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)