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MOLECULAR BASIS OF ANTIBIOTIC TRANSLOCATION

Objective

Multidrug resistant bacteria are now ubiquitous in both hospitals and the larger community. Drug-resistant pathogens are becoming increasingly pervasive, for example, the resurrection of tuberculosis provides one ominous example highlighting the risk associated with evolved drug resistance. Moreover, many pharmaceutical companies abandoned this field and no truly novel active antibacterial compounds are currently in clinical trials. Obviously we need new antibacterial molecules and maybe, novel strategies to develop antibiotics. The novel aspect here is to use state-in-the art techniques to quantify rate limiting steps of individual components involved antibiotic penetration and to validate them at the cellular level. Such a system biology approach identifies bottlenecks of existing antibiotics and might suggest novel antibiotic therapy. In Gram-negative bacteria, where influx and efflux systems located in the Outer Membrane represent a physical bottleneck for any antibiotic to reach a potential target. The aim is to investigate the molecular and cellular mechanisms at the basis of the influx and efflux processes and to teach scientists with different scientific background to go beyond the
classical faculty boarder. Bringing nanotechnology, physics, chemistry, computer modeling, pharmacology, microbiology together will facilitate the transfer of expertise acquired within the network in both academic and industry.
To achieve these goals we propose a training program allowing young researcher to collaborate across traditional faculty boarder. Three partners from the private sector will actively participate, the first one is a SME developing unique nanodevices allowing high-throughput drug screening in the field of electrophysiology, the second one is engaged in developing novel antibiotics and the third one is working on drug screening and characterization. Moreover three global pharmaceutical companies will accept students for secondments.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

JACOBS UNIVERSITY BREMEN GGMBH
Address
Campus Ring 1
28759 Bremen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 625 640,18
Administrative Contact
Ronald Kieschnick (Mr.)

Participants (10)

UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 663 400,72
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luciano Colombo (Prof.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom
EU contribution
€ 285 056,64
Address
North Street 66 College Gate
KY16 9AJ St Andrews
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Trish Starrs (Ms.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 285 056,64
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Amanda Gregory (Dr.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 222 068,88
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Pos (Prof.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 255 948,66
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 261 515,76
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dirk Bumann (Prof.)
BIOVERSYS AG
Switzerland
EU contribution
€ 261 515,76
Address
Hochbergerstrasse 60 C Technologiepark Basel
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Gitzinger (Dr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 222 068,88
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Michael Prestele (Mr.)
NANION TECHNOLOGIES GMBH
Germany
EU contribution
€ 222 068,88
Address
Ganghoferstrasse 70A
80339 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Niels Fertig (Dr.)
European ScreeningPort GmbH

Participation ended

Germany
Address
Schnackenburgallee
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philip Gribbon (Dr.)