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New Medicines for Trypanosomatidic Infections

Objective

The infectious diseases burden imposed by the parasites of Trypanosomatidae family represents a huge problem on people’s lives in countries where these diseases are endemic. Problems associated with existing drugs include inefficient delivery, insufficient efficacy, excessive toxicity and increasing resistance. New drugs are urgently needed now and in the foreseeable future. The New Medicine for Trypanosomatid Infections (NMTrypI) consortium uses a highly interdisciplinary approach to optimize pteridine, benzothiazole and miltefosine derivatives, as well as natural products against Trypanosomatids. The lead compounds target mechanisms that are associated with protozoa virulence and pathogenicity. The major objectives of this 3-year project are: i) development of drug leads which may be used in combination with a known or an investigational drugs, by using a common drug discovery platform established by experts in their respective fields, ii) development of pharmacodynamic biomarkers enabling the proteomic profiling of compound efficacy and early identification of drug resistance. NMTrypI addresses sleeping sickness, leishmaniasis, and Chagas disease. The partners are SMEs (5) and academics (8) in Europe and in disease-endemic countries (Italy, Greece, Portugal, Sudan, and Brazil). The new platform enables high throughput screening of compound libraries, lead development, testing in relevant animal models, as well as toxicology and safety testing. NMTrypI will translate drug leads into drug candidacy through 6 scientific work packages (WPs1-6) supported by two transversal WPs dedicated to project dissemination and management. The major strength of the consortium lies in the complementary partners’expertise and the integrated platform that will provide:
- at least 1-2 innovative, less toxic and safer drug candidates for Trypanosomatid infections compared to existing ones,
- early phase biomarkers for efficacy prediction (overall improved efficacy and safety)

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Coordinator

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Address
Via Universita 4
41121 Modena
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 889 824,31
Administrative Contact
Maria Paola Costi (Prof.)

Participants (13)

European ScreeningPort GmbH
Germany
EU contribution
€ 87 281,18
Address
Schnackenburgallee
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philip Gribbon (Dr.)
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany
EU contribution
€ 502 965
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Activity type
Research Organisations
Administrative Contact
Joachim Clos (Dr.)
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal
EU contribution
€ 469 318,80
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
Administrative Contact
Claudia Ferreira (Dr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 340 740
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefano Mangani (Prof.)
HITS GGMBH
Germany
EU contribution
€ 581 808,80
Address
Schloss Wolfsbrunnenweg 35
69118 Heidelberg
Activity type
Research Organisations
Administrative Contact
Rebecca Wade (Dr.)
TYDOCK PHARMA S.r.l
Italy
EU contribution
€ 388 570
Address
Strada Gherbella 294/B
41126 Modena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alberto Venturelli (Dr.)
NATIONAL CENTER FOR RESEARCH
Sudan
EU contribution
€ 158 860
Address
El-mak Nimir Street
11111 Khartoum
Activity type
Research Organisations
Administrative Contact
Adil Ahmed Abdallah (Mr.)
Hypha Discovery Limited
United Kingdom
EU contribution
€ 392 793,85
Address
Briar Cottages, Bakers Lane 1
SL6 6QH Maidenhead
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gillian Charles (Dr.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 447 492,19
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Ioanna Petrohilou (Mrs.)
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 445 484,80
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
María Isabel Rodríguez Villa (Mrs.)
Interface Europe

Participation ended

Belgium
EU contribution
€ 254 339,02
Address
Rue Du Trone 12
1000 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christiane Andriamandroso (Mrs.)
CENTRO NACIONAL DE PESQUISA EM ENERGIA E MATERIAS ASSOCIACAO PRIVADA
Brazil
EU contribution
€ 325 965,20
Address
Rua Giuseppe Maximo Scolfaro 10000
13083 100 Campinas
Activity type
Research Organisations
Administrative Contact
Milena Francelim Camargo
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 615 968
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Michael Prestele (Mr.)