Objectif This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical devices such as molecular rotors, walkers and logic devices, no such systems have been developed that operate across lipid membranes.Thus, by exploiting our knowledge of biological and synthetic supramolecular components we seek to construct some of the first ever transmembrane molecular machines built to man-made specifications. Mirroring the operation of biological transmembrane molecular machines, compartmentalisation facilitates the construction of nanomechanical devices that can be driven by electrochemical gradients, or those that operate in the reverse sense by turning over chemical fuels to establish non-equilibrium conditions. We intend to demonstrate these principles by combining nanopore-based techniques and DNA-recognition processes to assemble a range of membrane-spanning nanomechanical devices that can be operated, controlled and monitored down to single-molecule levels:Project 1 – Transmembrane logic & signalling on the single-molecule level.Project 2 – A transmembrane transporter.Project 3 – A transmembrane reciprocating pump.Project 4 – A transmembrane rotary motor. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsengineering and technologyenvironmental engineeringenergy and fuels Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2013-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil THE UNIVERSITY OF EDINBURGH Contribution de l’UE € 1 469 780,00 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Royaume-Uni Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Chercheur principal Scott Cockroft (Dr.) Contact administratif Alan Kennedy (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF EDINBURGH Royaume-Uni Contribution de l’UE € 1 469 780,00 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Chercheur principal Scott Cockroft (Dr.) Contact administratif Alan Kennedy (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée KATHOLIEKE UNIVERSITEIT LEUVEN Belgique Contribution de l’UE € 30 000,00 Adresse OUDE MARKT 13 3000 Leuven Voir sur la carte Région Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Type d’activité Higher or Secondary Education Establishments Contact administratif Elke Lammertyn (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
