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Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders

Objective

The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychotic disorders and associated metabolic co-morbidities. We aim to (1) optimise a multidisciplinary approach for combining positron emission tomography (PET) and magnetic resonance imaging (MRI) with metabolomics approaches, (2) develop a PET-method for exploring endocannabinoid pathways in early psychosis in longitudinal study setting, and (3) develop combined PET-MRI biomarker methodology for psychiatric disorders by studying neurotransmitter interactions with multiple PET scan and MRI sequences. The balance of two or more neurotransmitter systems may function as a novel biomarker in these disorders. The expected impacts are (1) etiopathogenic understanding, (2) new validated multi-modal markers for early disease detection and monitoring, (3) new tools for the identification of subjects who may benefit from specific treatment (4) discovery of new avenues for disease prevention and therapy, and (5) new tools and processes for applying brain imaging in personalised medicine. The consortium brings together clinicians, researchers and industry partners in the domains of psychiatry, neuroimaging, metabolic research, systems biology and bioinformatics.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /medical and health sciences/clinical medicine/psychiatry

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TURUN YLIOPISTO
Address
Yliopistonmaki
20014 Turku
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 957 512,35

Participants (10)

TEKNOLOGIAN TUTKIMUSKESKUS VTT

Participation ended

Finland
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
PHILIPS TECHNOLOGIE GMBH

Participation ended

Germany
Address
Luebeckertordamm 5
20099 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMAX INFORMATICS AG
Germany
EU contribution
€ 673 360
Address
Robert Koch Strasse 2
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 430 950
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
NOVO NORDISK INVEST 4 A/S

Participation ended

Denmark
EU contribution
€ 373 788,65
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 425 548
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
PHILIPS GMBH
Germany
EU contribution
€ 596 952
Address
Rontgenstrasse 22
22335 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 557 735
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Teknologian tutkimuskeskus VTT Oy
Finland
EU contribution
€ 178 273
Address
Vuorimiehentie 3
02150 Espoo
Activity type
Research Organisations
OREBRO UNIVERSITY
Sweden
EU contribution
€ 39 750
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments