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Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders

Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders

Objective

The theme of this collaborative project is development and application of neuroimaging and bioinformatics tools to study lipid metabolism as a common pathogenic link between psychotic disorders and its metabolic co-morbidities. The overall objective is to identify, prioritize and evaluate multi-modal blood and neuroimaging markers with diagnostic potential for prediction and monitoring of psychotic disorders and associated metabolic co-morbidities. We aim to (1) optimise a multidisciplinary approach for combining positron emission tomography (PET) and magnetic resonance imaging (MRI) with metabolomics approaches, (2) develop a PET-method for exploring endocannabinoid pathways in early psychosis in longitudinal study setting, and (3) develop combined PET-MRI biomarker methodology for psychiatric disorders by studying neurotransmitter interactions with multiple PET scan and MRI sequences. The balance of two or more neurotransmitter systems may function as a novel biomarker in these disorders. The expected impacts are (1) etiopathogenic understanding, (2) new validated multi-modal markers for early disease detection and monitoring, (3) new tools for the identification of subjects who may benefit from specific treatment (4) discovery of new avenues for disease prevention and therapy, and (5) new tools and processes for applying brain imaging in personalised medicine. The consortium brings together clinicians, researchers and industry partners in the domains of psychiatry, neuroimaging, metabolic research, systems biology and bioinformatics.

Coordinator

TURUN YLIOPISTO

Address

Yliopistonmaki
20014 Turku

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 957 512,35

Participants (10)

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TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

PHILIPS TECHNOLOGIE GMBH

Germany

BIOMAX INFORMATICS AG

Germany

EU Contribution

€ 673 360

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 430 950

Steno Diabetes Center A/S

Denmark

EU Contribution

€ 373 788,65

TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 425 548

Philips GmbH

Germany

EU Contribution

€ 596 952

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 557 735

Teknologian tutkimuskeskus VTT Oy

Finland

EU Contribution

€ 178 273

OREBRO UNIVERSITY

Sweden

EU Contribution

€ 39 750

Project information

Grant agreement ID: 602478

Status

Closed project

  • Start date

    1 September 2013

  • End date

    28 February 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 6 085 443,81

  • EU contribution

    € 4 233 869

Coordinated by:

TURUN YLIOPISTO

Finland

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