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Collaborative European NeuroTrauma Effectiveness Research in TBI

Collaborative European NeuroTrauma Effectiveness Research in TBI

Objective

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 patients, which will be used for better characterization of TBI and for Comparative Effectiveness Research (CER). The generalisability of our results will be reinforced by a contemporaneous registry level data collection in 15-25,000 patients. Our conceptual approach is to exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all severities of injury (mild to severe). Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by the US National Academy of Science, facilitating targeted management for individual patients. Our consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics expertise to the project. Collaborations with external partners, other FP7 consortia, and international links within InTBIR, will greatly augment scientific resources and broaden the global scope of our research. We anticipate that the project could revolutionize our view of TBI, leading to more effective and efficient therapy, thus improving outcome and reducing costs. These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and policy makers to make informed decisions, and will improve healthcare at both individual and population levels.

Coordinator

UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Address

Wilrijkstraat 10
2650 Edegem

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 11 728 072

Administrative Contact

Tomas Menovsky (Prof.)

Participants (42)

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TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

AZIENDA OSPEDALIERA SAN GERARDO DI MONZA

Italy

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 2 997 529

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 1 049 970

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 3 054 520

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

Germany

EU Contribution

€ 866 664

TRNAVSKA UNIVERZITA V TRNAVE

Slovakia

EU Contribution

€ 399 955

PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS

Hungary

EU Contribution

€ 1 652 438

VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA

Finland

EU Contribution

€ 48 596

ICOMETRIX NV

Belgium

EU Contribution

€ 2 110 000

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 533 706

AZIENDA SOCIO-SANITARIA TERRITORIALE (ASST) DI MONZA

Italy

EU Contribution

€ 61 741

GENOME RESEARCH LIMITED

United Kingdom

MEDICAL RESEARCH COUNCIL

United Kingdom

Private Universitaet Witten/Herdecke gGmbH

Germany

EU Contribution

€ 376 324

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 163 858

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 401 775

UNIVERSITE DE LIEGE

Belgium

EU Contribution

€ 203 874

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 173 130

GREATER GLASGOW HEALTH BOARD

United Kingdom

EU Contribution

€ 126 951

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 85 000

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 211 676

Teknologian tutkimuskeskus VTT Oy

Finland

EU Contribution

€ 224 455

THE UNIVERSITY OF STIRLING

United Kingdom

EU Contribution

€ 224 684

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 46 924

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 109 908

OXFORD BROOKES UNIVERSITY

United Kingdom

EU Contribution

€ 197 230

NHS BLOOD AND TRANSPLANT

United Kingdom

EU Contribution

€ 22 100

FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO

Italy

EU Contribution

€ 327 000

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 1 391 982

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

EU Contribution

€ 93 225

University of Florida

United States

EU Contribution

€ 79 999

University of Cincinnati

United States

EU Contribution

€ 32 000

MONASH UNIVERSITY

Australia

EU Contribution

€ 279 499

AUCKLAND UNIVERSITY OF TECHNOLOGY

New Zealand

EU Contribution

€ 25 000

RENJI HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE

China

EU Contribution

€ 50 000

UNIVERSITAET GREIFSWALD

Germany

EU Contribution

€ 19 000

INTERNATIONALE GESELLSCHAFT ZUR ERFORSCHUNG VON HIRNTRAUMATA

Austria

EU Contribution

€ 10 346

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 37 000

ARTTIC

France

EU Contribution

€ 355 168

QUESGEN SYSTEMS, INC

United States

EU Contribution

€ 127 500

UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

Italy

EU Contribution

€ 100 104

Project information

Grant agreement ID: 602150

Status

Ongoing project

  • Start date

    1 October 2013

  • End date

    31 March 2020

Funded under:

FP7-HEALTH

  • Overall budget:

    € 39 006 741,89

  • EU contribution

    € 29 998 903

Coordinated by:

UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Belgium