CORDIS
EU research results

CORDIS

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Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope

Project information

Grant agreement ID: 602299

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 674 687,79

  • EU contribution

    € 5 999 562

Coordinated by:

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

Germany

Objective

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and costs supporting current guideline recommendations may be outdated, and the influence of gender remains unclear.
EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe) aims to generate contemporary clinical outcome data on ICD effectiveness in Europe. Clinical outcomes including all-cause mortality, appropriate and inappropriate ICD shocks, and quality of life (QoL) are assessed by:
- a prospective study of patients undergoing indicated ICD treatment for primary SCD prevention, with a control group of patients not undergoing ICD treatment
- a large European registry collecting available data on prophylactic ICD treatment
- meta-analyses of available and emerging ICD outcome studies
QoL-adjusted cost-effectiveness will be estimated from actual cost comparisons and Markov decision models with attention to sub-groups, regional, and sex comparisons. Outcomes in patients receiving ICDs for primary SCD prevention will be compared in sub-strata, and with patients fulfilling guideline criteria but not undergoing therapy as per prior decision of treating physicians. Sub-groups with particularly large or small benefit from ICD implantation will be identified using risk markers and clinical characteristics with specific emphasis on gender. EU-CERT-ICD is expected to provide important novel information to validate or challenge current guideline indications for primary prophylactic ICD treatment.

Coordinator

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

Address

Robert-Koch-Strasse 40
37075 Goettingen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 290 586,24

Administrative Contact

Christiane Hennecke (Mrs.)

Participants (25)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 345 613,20

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 70 440

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 44 763,60

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 144 100,80

PANEPISTIMIAKO GENIKO NOSOKOMEIO ATTIKON

Greece

EU Contribution

€ 106 778,40

SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE

Slovakia

EU Contribution

€ 73 416

OULUN YLIOPISTO

Finland

EU Contribution

€ 225 723,60

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 263 338,80

UNIVERSYTET MEDYCZNY W LODZI.

Poland

EU Contribution

€ 228 649,20

ST. PAUL'S CARDIAC ELECTROPHYSIOLOGY LLP

United Kingdom

EU Contribution

€ 139 814,40

SEMMELWEIS EGYETEM

Hungary

EU Contribution

€ 269 733,60

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 314 916

UNIVERSITATSSPITAL BASEL

Switzerland

EU Contribution

€ 256 549,20

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 249 133,20

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 169 838,40

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 478 800

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 160 889,36

MAGDALENA - KLINIKA ZA KARDIOVASKULARNE BOLESTI MEDICINSKOG FAKULTETASVEUCILISTA J.J. STROSSMAYERA U OSIJEKU USTANOVA

Croatia

EU Contribution

€ 67 778

KLINIKEN LUDWIGSBURG-BIETIGHEIM GGMBH

Germany

EU Contribution

€ 12 300

FAKULTNI NEMOCNICE BRNO

Czechia

EU Contribution

€ 26 400

SKANE LANS LANDSTING

Sweden

STREDOSLOVENSKY USTAV SRDCOVYCH A CIEVNYCH CHOROB AS

Slovakia

EU Contribution

€ 16 800

SZPITAL KLINICZNY IM HELIODORA SWIECICKIEGO UNIWERSYTETU MEDYCZNEGO IMKAROLA MARCINKOWSKIEGO W POZNANIU

Poland

EU Contribution

€ 16 200

UNIVERZITA PALACKEHO V OLOMOUCI

Czechia

EU Contribution

€ 21 600

INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

Poland

EU Contribution

€ 5 400

Project information

Grant agreement ID: 602299

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2018

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 674 687,79

  • EU contribution

    € 5 999 562

Coordinated by:

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

Germany