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Targeted Action for Curing Trauma Induced Coagulopathy

Objective

Trauma remains one of the world’s biggest contributors to the global burden of disease. Predominantly affecting young adults and children, 800,000 European injury related deaths were recorded in 2002. Outcomes for critically injured trauma patients remain poor with severe bleeding, brain injury and tissue damage being associated with high mortality and disability. Nearly half of all trauma fatalities result from haemorrhage, with many patients developing a clotting disorder (coagulaopthy) within minutes of injury or during their clinical care, that worsens bleeding and hampers emergency surgery. Current treatment of bleeding and coagulopathy is based on empirical ”blind” administration of blood products, with large variations in practice between trauma centres.

Important advances in care will only be made by a coordinated European national level approach that pulls discovery research into patients, into clinical guidelines and into national and global policy. “Targeted Action for Curing Trauma Induced Coagulopathy” (TACTIC) is a comprehensive programme of comparative clinical research that will deliver this quantum step in the global health care management of coagulopathic trauma patients, and potentially all patients with acute critical illness.

TACTIC will recruit patients from a network of trauma centres in Amsterdam, Cologne, Copenhagen, London, Oslo and Oxford to compare the effectiveness of different current practices across Europe. It will deliver universal guidelines for how coagulaopathy should be monitored and treated, enabling the individualised treatment of all critically bleeding patients, and and resolve barriers to the subsequent continental implementation of patient-matched targeted transfusion policy, which is expected to reduce trauma haemorrhage-related mortality by approximately ten percent, saving 30.000 lives per year as well as significantly reducing hospital and societal costs.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /social sciences/sociology/demography/mortality

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

REGION HOVEDSTADEN
Address
Kongens Vaenge 2
3400 Hillerod
Denmark
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 3 521 216,60
Administrative Contact
Pär Johansson (Prof.)

Participants (8)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 251 778,80
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Niels Bartels (Mr.)
Private Universitaet Witten/Herdecke gGmbH
Germany
EU contribution
€ 200 366
Address
Alfred-herrhaussen Strasse 50
58448 Witten
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marc Maegele (Prof.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 172 182
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christine Gaarder (Dr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 1 417 827,91
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karim Brohi (Prof.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Participation ended

United Kingdom
EU contribution
€ 74 142,82
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
HAEMONETICS CORPORATION
United States
EU contribution
€ 54 311
Address
Wood Road 400
02184 Braintree Ma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ahmed Char (Mr.)
TEM INNOVATIONS GMBH
Germany
EU contribution
€ 87 092
Address
Martin Kollar Strasse 13-15
81829 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dieter Ober-Jung (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 101 093,18
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tine Mathiesen