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EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma

Objective

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES occurring in the EU each year, less than half will receive treatment ‘appropriate’ to deliver the most favourable outcome. The EUROEWING Consortium (EEC) is a coalition of clinical study groups bringing together the most active clinicians and scientists in Europe dedicated to improving survival from ES. This initiative can achieve this through an integrated programme of investigator-driven, inclusive clinical trials that are rigorously designed, conducted, analysed and reported, and underpinned by complementary embedded translational research. These include i) a first line randomised study in patients of all ages with ES which defines standards of care to prevent development of metastases and serves as a backbone for implementation of new agents, and ii) a randomised study of current second line chemotherapy in patients of all ages with ES which will serve as a platform for testing of new agents. Companion studies in association with these trials will be performed investigating tumour biology, underlying causes of differential response and toxicity, and other biomarkers. The programme will be supported by new initiatives for the involvement of patients in research planning and operation. Through collaborative working, the EEC will provide ES patients with greater access to clinical trials, allow efficient acquisition of knowledge and deliver clinically meaningful results within the lifetime of the grant, thereby contributing to improved survival from ES.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
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Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Browne Michael (Mr.)
EU contribution
€ 785 616,32

Participants (20)

EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Belgium
EU contribution
€ 648 804,01
Address
Avenue E. Mounier 83
1200 Brussels

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Activity type
Research Organisations
Administrative Contact
Stephane Lejeune (Mr.)
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
France
EU contribution
€ 524 761
Address
Rue Laennec 28
69373 Lyon

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Activity type
Research Organisations
Administrative Contact
Marina Rousseau Tsangaris (Mrs.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Participation ended

Germany
EU contribution
€ 218 967,78
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingo Niendorf (Mr.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 1 087 268
Address
Edgbaston
B15 2TT Birmingham

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 118 999,20
Address
Oxford Road
M13 9PL Manchester

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 75 583,20
Address
Albinusdreef 2
2333 ZA Leiden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marlina Vos (Mrs.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 72 430,80
Address
Rue Camille Desmoulins 39
94805 Villejuif

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Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)
INSTITUT CURIE
France
EU contribution
€ 255 510
Address
Rue D Ulm 26
75231 Paris

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Activity type
Research Organisations
Administrative Contact
Corinne Cumin (Mrs.)
GRUPO ESPANOL DE INVESTIGACION EN SARCOMAS ASOCIACION
Spain
EU contribution
€ 476 716,40
Address
Calle Velazquez 7 3rd Floor
28001 Madrid

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Activity type
Research Organisations
Administrative Contact
Patricio Ledesma (Mr.)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 106 200
Address
Avenida De La Constitucion 18
41071 Sevilla

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Sophie Monteau (Ms.)
ST ANNA KINDERKREBSFORSCHUNG VEREIN
Austria
EU contribution
€ 118 200
Address
Zimmermannplatz 10
1090 Wien

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Activity type
Research Organisations
Administrative Contact
Andrade Nuno (Dr.)
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 294 717,50
Address
Via Di Barbiano 1/10
40136 Bologna

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Activity type
Research Organisations
Administrative Contact
Andrea Rizzi (Dr.)
REGION SKANE
Sweden
EU contribution
€ 73 008
Address
Region Skane
291 89 Kristianstad

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Mikael Eriksson (Dr.)
INNOVATIVE THERAPIES FOR CHILDREN WITH CANCER ASSOCIATION
France
Address
Rue Edouard Vaillant 114
94800 Villejuif

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Activity type
Research Organisations
Administrative Contact
Bruce Morland (Dr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 522 904,07
Address
Woodhouse Lane
LS2 9JT Leeds

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Hamilton (Mr.)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 13 660,80
Address
Maximiliansplatz 2
91054 Erlangen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Faber (Dr.)
SARCOMA PATIENTS EURONET EV
Germany
EU contribution
€ 19 440
Address
Untergasse 36
61200 Wolfersheim

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Activity type
Other
Administrative Contact
Michaela Geissler (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 27 600
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mohamed El Ouassghiri (Mr.)
UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 69 024,60
Address
Euston Road 250
NW1 2PG London

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Activity type
Research Organisations
Administrative Contact
Joe Mwanza (Mr.)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 188 419,22
Address
Hufelandstrasse 55
45147 Essen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nora Manzke (Dr.)