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European network for innovative microbioreactor applications in bioprocess development

Objective

The objective is to deliver a trans-European network of industrially oriented specialists fully trained in the development and application of microbioreactor (MBR) technology to support development of innovative bio-based manufacturing processes. The specialistis will be trained by leaders in the field and with state of the art equipment and methodologies. MBRs are a promising tool for screening and scale-up of fermentation and biocatalysis processes due to their low production cost, small working volumes, flexibility and their potential for information-rich experiments under well-controlled experimental conditions. In this consortium, we will further develop MBRs for chemical and biochemical screening, paying special attention to MBR parallelization and applicability for different applications. In addition, characterization of experimental uncertainty, development of reactant feeding strategies at micro-scale and coupling of microscale experimentation to automated design of experiments (DoE) will document applicability of MBRs for chemical and biochemical research. To enhance the applicability of microfluidic enzymatic reactors for organic synthesis, we will establish microfluidic chemo-biocatalytic reaction systems that enable rapid characterization of biosynthetic pathways and chemo-enzymatic conversions. This will be underpinned with immobilization methods that permit rapid and reversible binding of a range of biocatalysts and modeling that relates the kinetic data with results from larger scales. Complemented with precisely positioned fluorescence-based sensor arrays, novel nanosensor particle concepts, and integrated Raman and NIR probes, the MBRs will deliver the data-rich experimentation needed for industrial applications. Data processing and information management will be accomplished by developing CFD and mathematical modeling methods that permit prediction and interpretation of fermentation and biocatalytic processes in MBRs.

Call for proposal

FP7-PEOPLE-2013-ITN
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Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrich Krühne (Dr.)
EU contribution
€ 1 032 348,97

Participants (11)

UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 583 313,28
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giles Machell (Mr.)
TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 493 603,44
Address
Rechbauerstrasse 12
8010 Graz

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Torsten Mayr (Dr.)
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 440 795,52
Address
Kongresni Trg 12
1000 Ljubljana

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Polona Znidarsic-Plazl (Dr.)
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG
Germany
EU contribution
€ 235 268,88
Address
Universitaetsplatz 2
38106 Braunschweig

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rainer Krull (Prof.)
OULUN YLIOPISTO
Finland
EU contribution
€ 274 397,64
Address
Pentti Kaiteran Katu 1
90014 Oulu

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hanna Honkamakila (Ms.)
UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Italy
EU contribution
€ 254 037,96
Address
Viale Europa Localita Germaneto
88100 Catanzaro

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerardo Perozziello (Dr.)
MICRONIT HOLDING BV
Netherlands
EU contribution
€ 166 842,56
Address
Colosseum 15
7521 PV Enschede

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marko Blom (Dr.)
MICROFLUIDIC CHIPSHOP GMBH
Germany
EU contribution
€ 156 300,54
Address
Stockholmer Strasse 20
07747 Jena

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Claudia Gärtner (Dr.)
IX-FACTORY GMBH
Germany
EU contribution
€ 156 300,54
Address
Konrad Adenauer Allee 11
44263 Dortmund

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dominique Bouwes (Mrs)
NANOMATERIALES Y POLIMEROS SL
Spain
EU contribution
€ 159 587,84
Address
Avenida De La Innovacion 1, Edificio Bic
18100 Armilla Granada

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jorge Fernandez-Sanchez (Dr.)
CERCELL APS

Participation ended

Denmark
EU contribution
€ 30 259,01
Address
Malmmosevej 19 C
2840 Holte
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Per Stobbe (Mr.)