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Personalised Prognostic Tools for Early Psychosis Management

Objective

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early adulthood and long-term disabling disease courses. Both factors lead to enduring social and vocational exclusion and contribute to 8-20 times higher suicide rates in affected patients.
Reliable and accessible prognostic tools will alleviate this burden by enabling individualised risk prediction, thus facilitating the targeted prevention of psychoses. Thus, we will first use routine brain imaging and complementary data to optimise our candidate biomarkers for the prediction and staging of psychoses and generate a prognostic system that generalises well across mental health services. Secondly, we will implement new multi-modal risk quantification tools to predict mental health-related disability in young help-seekers. The fusion of these tools with clinical knowledge will produce cybernetic prognostic services that accurately identify help-seekers at the highest risk of psychosis, poor functioning and suicide-related mortality.
During this project we will secure our intellectual property rights and transform into a European company to commercially exploit these prognostic services through internet-based telemedicine applications. This will provide psychosis risk profiling tools to diverse target groups in the healthcare markets, including care-givers, the pharmaceutical industry and research institutions. By disseminating objective risk quantification, these products will provide firm diagnostic grounds for preventive therapy, improving outcomes and reducing costs. Thus, they will offer a unique selling proposition to the mental health sectors in Europe and beyond.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
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Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nikolaos Koutsouleris (Dr.)
EU contribution
€ 840 628

Participants (17)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 615 808
Address
Petersplatz 1
4051 Basel

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefan Borgwardt (Prof.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 637 700
Address
Kerpener Strasse 62
50937 Koeln

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schreiner-Kaub (Mrs.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 677 265
Address
Edgbaston
B15 2TT Birmingham

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
TURUN YLIOPISTO
Finland
EU contribution
€ 672 919
Address
Yliopistonmaki
20014 Turku

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mari Riipinen (Dr.)
UNIVERSITA DEGLI STUDI DI UDINE
Italy
EU contribution
€ 338 151
Address
Via Palladio 8
33100 Udine

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marina Dorligh
UNIVERSITY OF MELBOURNE
Australia
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Melinda Heron (Ms.)
DYNAMIC EVOLUTION GMBH
Germany
EU contribution
€ 833 220
Address
Lichtenbergstrasse 8
85748 Garching

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Jovicevic (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 188 997
Address
Oskar Von Miller Ring 29
80333 Muenchen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH
Germany
EU contribution
€ 545 444
Address
Bleichstrasse 64-66
60313 Frankfurt Am Main

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Manuela Abraham
GE HEALTHCARE GMBH - GEHC
Germany
EU contribution
€ 21 425
Address
Beethovenstrasse 239
42655 Solingen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Schirmer (Dr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 335 744
Address
Via Festa Del Perdono 7
20122 Milano

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Antonia Giofrè (Dr.)
ARTTIC
France
EU contribution
€ 125 639
Address
39 Rue Des Mathurins
75008 Paris

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 35 850
Address
Schlossplatz 2
48149 Muenster

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katharina Steinberg (Dr.)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 35 850
Address
Piazza Umberto I 1
70121 Bari

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riccarda Lomuscio
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 35 360
Address
Universitaetsstrasse 1
40225 Dusseldorf

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eftimia Latrovali
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 60 000
Address
Venusberg-campus 1
53127 Bonn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Mrs.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Address
Hofgartenstrasse 8
80539 Munchen

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Activity type
Research Organisations
Administrative Contact
Ralf Tatzel (Dr.)