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Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine

Objetivo

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.

ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level neuroscientists, bioinformatics and ncRNA experts. In order to gain knowledge on the mechanisms of chronic pain, ncRNAPain will investigate ncRNAs specifically in neurogenic and neuropathic pain, including headache.

ncRNAPain will provide novel understanding of ncRNA regulation of processes modulating nociception and endogenous analgesia and of the importance of ncRNAs in circuitries and cognitive, emotional and behavioural components of pain. ncRNAPain will reveal insights into the concerted function of ncRNAs in the control of macromolecular complexes in neurons, glia and immune cells and signals used for neuroimmune communication in the pain pathway. Based on these findings, ncRNAPain will identify and validate specific ncRNAs as new druggable molecular targets for pain prevention and relief. ncRNAPain will identify pain predisposing ncRNA expression patterns and polymorphisms in ncRNAS and/or their binding sites as biomarkers for pain and inter-individual variations in the response to painful stimuli and analgesic drugs. ncRNA-based diagnostic tools will be developed and provided to enable better patient stratification, improved mechanism-based treatment and targeted prevention strategies for high risk individuals.

ncRNAPain will provide novel understanding of the induction and maintenance of chronic pain and is committed to translate pre-clinical and clinical results and developments into clinical applications for the benefit of the patients, to improve the patients’ quality of life and reduce the societal burden of chronic pain across Europe.

Convocatoria de propuestas

FP7-HEALTH-2013-INNOVATION-1
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Coordinador

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Dirección
Christoph Probst Platz 1
6020 Innsbruck
Austria
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 1 699 160
Contacto administrativo
Wolfram Rieneck (Dr.)

Participantes (11)

UNIVERSITE VICTOR SEGALEN BORDEAUX II

La participación finalizó

Francia
Dirección
Rue Leo Saignat 146
33076 Bordeaux Cedex
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Adeline Barre (Ms.)
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Alemania
Aportación de la UE
€ 581 140
Dirección
Josef-schneider-strasse 2
97080 Wurzburg
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Melanie Bauer
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Alemania
Aportación de la UE
€ 398 826
Dirección
Langenbeckstrasse 1
55131 Mainz
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Uta Veith (Dr.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Alemania
Aportación de la UE
€ 428 100
Dirección
Heinrich-hertz-allee 1
66386 St Ingbert
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Vera Schneider (Dr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Alemania
Aportación de la UE
€ 392 640
Dirección
Im Neuenheimer Feld 672
69120 Heidelberg
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Thorsten Brietz (Mr.)
KING'S COLLEGE LONDON
United Kingdom
Aportación de la UE
€ 400 920
Dirección
Strand
WC2R 2LS London
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Paul Labbett (Mr.)
Masarykova univerzita
Chequia
Aportación de la UE
€ 310 933
Dirección
Zerotinovo Namesti 9
601 77 Brno
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jakub Zeman (Mr.)
UNIVERSITE DE BORDEAUX
Francia
Aportación de la UE
€ 362 640
Dirección
Place Pey Berland 35
33000 Bordeaux
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Adeline Barre (Ms.)
EXIQON AS
Dinamarca
Aportación de la UE
€ 467 916
Dirección
Bygstubben 9
2950 Vedbaek
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Peter Mouritzen (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Aportación de la UE
€ 525 960
Dirección
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jane Turner (Ms.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Alemania
Aportación de la UE
€ 420 600
Dirección
Meyerhofstrasse 1
69117 Heidelberg
Tipo de actividad
Research Organisations
Contacto administrativo
Phil Irving (Dr.)