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Health and the Understanding of Metabolism, Aging and Nutrition

Objective

Recently intense research identified around 4,000 single nucleotide polymorphisms (SNPs) associated with human age related diseases such as metabolic disorders. Despite their highly significant association to pathology, the functional role of these genetic variants is, in most cases, yet to be elucidated. The evolutionary distance of most animal models from humans represents a major limitation for the functional validation of these SNPs. To overcome these difficulties, HUMAN will generate mouse models carrying human hepatocytes or pancreatic βcells from either primary cells (hepatocytes) or induced pluripotent stem cells (iPSCs). This innovative approach offers the unique possibility of studying function of genetic risk variants associated with metabolic diseases in an integrated living system (the mouse body), but within human-derived organs, i.e. liver and pancreas. iPSCs used to generate hepatocytes and βcells will derive from extreme phenotypes, i.e. patients affected by severe metabolic diseases such as type 2 diabetes (T2D) or subjects selected for exceptional healthy longevity (subjects over 105 years and offspring of nonagenarian sibships) all fully clinically and metabolically characterised and genotyped; they will be selected according to the best combination of risk and protective alleles. We will test the effect of different nutritional regimes (e.g. high fat diet, caloric restriction), to disentangle the complex molecular mechanisms and circuitry across organs (e.g. hypothalamus-liver axis) which lead to pathology. HUMAN associates a core of outstanding basic research institutions to leading European biotech SMEs, and has the capability to produce at least 500 humanised mice. HUMAN will generate iPSCs biobanks and comprehensively manage all associated information. HUMAN is uniquely situated to drive innovation towards a better knowledge of the genetic basis of human metabolic diseases, thereby contributing to healthier aging of European citizens.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
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Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jenny Degerholm Langsmo (Mrs.)
EU contribution
€ 4 027 080

Participants (15)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 574 500
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Brice Kerber (Mr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 397 000
Address
Via Festa Del Perdono 7
20122 Milano

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sergio Longo (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 412 750
Address
Albinusdreef 2
2333 ZA Leiden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacobus De Graaf (Mr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 183 160
Address
Strand
WC2R 2LS London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labett (Mr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 514 000
Address
Via Zamboni 33
40126 Bologna

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mario Soffritti (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 615 116
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kamila Kolasinska (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 234 575
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
Université Paris Diderot-Paris 7
France
EU contribution
€ 523 000
Address
Rue Thomas Mann
F-75205 / 13 Paris

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne-Sophie Réfloc'h (Ms.)
AcureOmics AB
Sweden
EU contribution
€ 683 650
Address
Tvistevagen 48
SE-90187 Umeå

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johan Trygg (Prof.)
ACURE PHARMA AB

Participation ended

Sweden
Address
Ullerakersvagen 38
756 43 Uppsala

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Torbjörn Lundstedt (Prof.)
YECURIS CORPORATION FOR PROFIT CORPORATION
United States
EU contribution
€ 1 404 660
Address
Sw Sequoia Parkway 15055 Suite 130
97223 Tigard Oregon

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Bial (Mr.)
GATC BIOTECH AG
Germany
EU contribution
€ 749 749
Address
Jakob Stadler Platz 7
78467 Konstanz

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natascha Ostrowski (Ms.)
PRONEXUS ANALYTICAL AB
Sweden
EU contribution
€ 200 565
Address
Fogdevreten 2a
17177 Stockholm

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Kehr (Dr.)
GENEDATA AG
Switzerland
EU contribution
€ 746 748
Address
Margarethenstrasse 38
4053 Basel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Wittenberger (Dr.)
NESTEC SA
Switzerland
EU contribution
€ 728 000
Address
Epfl Innovation Park Building H
1015 Lausanne

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Nichols (Mr.)