Obiettivo Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artificial pancreases are in development but still dependent by external energy sources and need permanent transcutaneous access to release the hormone. Pancreatic whole organ transplantation is a major intervention requiring selected recipient and matched cadaveric donor which keep numbers down. Islet of Langerhans transplantation is a non-invasive method for the treatment of type 1 diabetes but several questions remain and several issues have to be addressed in order to improve the method since islet engraftment is clearly suboptimal, as a result of pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation, the long-term islet graft function drops to 15% with time, and the current systemic immunosuppressive regimen has several drawbacks in terms of side effects. Solution should be find to increase transplantation efficiency with an higher number of islet, eventually from animals, induce tolerance toward the graft, avoiding systemic, lifetime immunosuppression and, lowering a specific inflammatory reaction and enhancing graft micro vasculogenesis to improve islet nesting. NEXT provides a 360° solution to the pitfalls of current methodology for pancreatic islet transplantation: i) Nano technologies, to engineer donor cell surfaces in order to derange recognition and suppress their rejection; ii) Advanced tissue engineering methods, to assemble bio synthetic islet, enriched by chimeric microvasculature; iii) Innovative double immune-suppressive strategy by graft - bound immunosuppressive nano peptides and shielded by self- vasculature Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologytissue engineeringartificial pancreasmedical and health sciencesclinical medicinetransplantation Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.1.3-2 - Innovative approaches to address adverse immune reactions to biomedical devices, implants and transplant tissues Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore UNIVERSITY OF BRIGHTON Contributo UE € 670 581,20 Indirizzo LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Regno Unito Mostra sulla mappa Regione South East (England) Surrey, East and West Sussex Brighton and Hove Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Matteo Santin (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto EXPLORA SRL Italia Contributo UE € 1 125 385,40 Indirizzo Via Giacomo Peroni 386 00131 Roma Mostra sulla mappa Regione Centro (IT) Lazio Roma Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Federica Marotti (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CELLON SA Lussemburgo Contributo UE € 450 875,00 Indirizzo RUE HEIERCHEN 16 ZAE ROBERT STEICHEN 4940 BASCHARAGE Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Richard Fry (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITE DE GENEVE Svizzera Contributo UE € 764 208,40 Indirizzo RUE DU GENERAL DUFOUR 24 1211 Geneve Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Genève Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Thierry Berney (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato AvantiCell Science Ltd Regno Unito Contributo UE € 875 023,40 Indirizzo GIBBSYARD BUILDING KA6 5HW Ayr Mostra sulla mappa Regione Scotland Southern Scotland South Ayrshire Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Joanna Oliver (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ISTITUTO MEDITERRANEO PER I TRAPIANTI E TERAPIE AD ALTA SPECIALIZZAZIONE SRL - ISMETT SRL Italia Contributo UE € 855 653,00 Indirizzo DISCESA DEI GIUDICI 4 90133 Palermo Mostra sulla mappa Regione Isole Sicilia Palermo Tipo di attività Other Contatto amministrativo Fabrizio Campisi (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato