CORDIS
EU research results

CORDIS

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Epilepsies of the temporal lobe: emergence,
basal state and paroxysmal transitions

Project information

Grant agreement ID: 322721

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2018

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 985 057

  • EU contribution

    € 1 985 057

Hosted by:

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE

France

Objective

This proposal focuses on a human disease: epilepsy of the temporal lobe. This syndrome has a relatively stereotyped history. Focal seizures emerge, with a delay of several years in the human, after an initial insult that results in neuronal death. We will use physiology, imaging, anatomy and transcriptomic techniques to ask how an epileptic brain emerges, to define different neuronal cell types in the basal epileptic state and to examine factors associated with the paroxysmal transition to a seizure. Specifically we will ask whether a loss of cholesterol homeostasis is involved in the initial sclerotic neuronal death. We will ask whether proteoglycans deposited in the extracellular space as a generalised wound healing response force the establishment of aberrant synaptic contacts and so facilitate the slow process of epileptogenesis. We will then study the basal state of an epileptic brain. We will establish the physiology, anatomy, connectivity and transcriptome of functionally distinct neurons defined by different contributions to epileptiform activities in human epileptic brain slices. Finally we will seek to establish what sudden changes in field potential, ionic homeostasis, cellular firing and synaptic interactions are associated with the paroxysmal moment of transition to seizure.

Principal Investigator

Richard Miles (Dr.)

Host institution

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE

Address

Boulevard De L'Hopital 47
75013 Paris

France

Activity type

Research Organisations

EU Contribution

€ 1 985 057

Principal Investigator

Richard Miles (Dr.)

Administrative Contact

Alexandra Auffret (Dr.)

Beneficiaries (1)

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE

France

EU Contribution

€ 1 985 057

Project information

Grant agreement ID: 322721

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2018

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 1 985 057

  • EU contribution

    € 1 985 057

Hosted by:

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE

France