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Small Artery Remodelling

Small Artery Remodelling

Objective

Cardiovascular disease remains a major cause of morbidity and mortality in Europe. Small arteries form a key element in the pathogenesis. Thus, these vessels dictate local perfusion and blood pressure by adaptation of their caliber. Structural changes towards smaller caliber, small artery remodelling, cause hypertension and decreased organ perfusion, leading to acute events and chronic end organ dysfunction. Despite this role, these vessels are poorly studied and therapeutic options based on these arteries are lacking.

SmArteR (Small Artery Remodelling) collects 13 academic and SME partners who have set up a training programme for 12 ESRs and 3 ERs. We address the interaction between cells, extracellular matrix and mechanical loading in an integrative way, taking advantage of the multidisciplinary partnership. Thus, we will unravel the processes in small artery remodelling at the molecular, cellular and integrative physiology level, and we will develop novel and marketable technology aimed at studying these vessels in vitro under the right biomechanical conditions.

The ESRs and ERs are trained in not only cardiovascular R&D, but also in a range of skills required to form the new generation of frontrunners in biomedical research in academia and industry.

Coordinator

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Address

Meibergdreef 9
1105az Amsterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 903 972,02

Administrative Contact

Eugenie Quartier (Mrs.)

Participants (10)

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WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 444 137,76

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 222 068,88

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 284 579,46

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 259 925,16

UNIVERSITE DE FRIBOURG

Switzerland

EU Contribution

€ 261 515,76

PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS

Hungary

EU Contribution

€ 197 255,52

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 444 137,76

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 285 056,64

LIFETEC GROUP BV

Netherlands

EU Contribution

€ 358 499,30

DANISH MYO TECHNOLOGY AS

Denmark

EU Contribution

€ 250 198,74

Project information

Grant agreement ID: 606998

Status

Closed project

  • Start date

    1 November 2013

  • End date

    31 January 2018

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 3 911 347

  • EU contribution

    € 3 911 347

Coordinated by:

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands