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Developing a validated technology platform for the application of oxygen dependent enzymes in synthesis and transformation of alcohols

Objective

Currently the aerobic bio-catalytic oxidation reaction is the one that would have the biggest impact on the future uptake of industrial biotechnology in Europe. Chemical oxidation is both hazardous and has high environment impacts. Many oxidative bio-catalytic reactions and transformations have been identified in academic laboratories but only a very small number have been applied by industry to oxidize non-natural substrates.
Hence biocatalysis for oxidative chemical manufacture processes can deliver a major advantage to the European chemical-using industries and the environment. In this project we intend to develop the tools for implementation of bio-oxidation to synthesize and oxidize alcohols.
Cytochrome P450 enzymes will be investigated for hydroxylation of fatty acid derivatives and terpenes which have potential to be used in biopolymers and fragrance chemicals respectively form one line of investigation. The second is the selective oxidation of primary alcohols to give products with added value in their own right and as intermediates towards other valuable products.
To support the implementation culture collections and literature reported DNA sequences will be used to identify diverse enzymes with predicted oxidase activities, which will be used as starting point for an enzyme improvement program. Then fermentation and enzyme formulation techniques will improve reaction performance to a level where useful quantities of target products can be produced for evaluation by industrial partners, and engineering techniques will analyse and implement reactor configurations that will further improve this technology platform to enable this technology to be introduced as a routine technology in the IB industry and support the European KBBE.
Further a dynamic public engagement and dissemination program will be used to promote the project, IB and the FP7 program within the science community and the public, especially schoolchildren, to create extra value for the funders.

Call for proposal

FP7-KBBE-2013-7-single-stage
See other projects for this call

Coordinator

THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
M13 9PL Manchester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 092 286
Administrative Contact
Liz Fay (Ms.)

Participants (11)

UNIVERSITY OF STUTTGART
Germany
EU contribution
€ 719 520
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernhard Hauer (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 797 674,75
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
John Woodley (Prof.)
BICT SRL
Italy
EU contribution
€ 356 311
Address
Via Fratelli Sommariva 3
26818 Villanova Del Sillaro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberto Verga (Dr.)
CLEA TECHNOLOGIES BV

Participation ended

Netherlands
EU contribution
€ 313 348,50
Address
Delftechpark 34
2628 XH Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivo Van Der Laan (Mr.)
PROZOMIX LIMITED
United Kingdom
EU contribution
€ 440 029
Address
Station Court 3
NE49 9HN Haltwhistle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Charnock (Dr.)
C-TECH INNOVATION LIMITED
United Kingdom
EU contribution
€ 416 229,75
Address
Capenhurst Technology Park
CH1 6EH Chester
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kay Mcclean (Dr.)
BASF SE
Germany
EU contribution
€ 253 751
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Roeper (Prof.)
BIO-PRODICT BV
Netherlands
EU contribution
€ 380 241
Address
Nieuwe Marktstraat 54
6511 AA Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henk-Jan Joosten (Dr.)
FIRMENICH SA
Switzerland
EU contribution
€ 430 500
Address
Route Des Jeunes 1
1227 Geneve
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andreas Taglieber (Dr.)
CHEMISTRY INNOVATION LIMITED

Participation ended

United Kingdom
EU contribution
€ 5 262,48
Address
Burlington House Picadilly
W1J 0BA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rebecca Wood (Mrs.)
KNOWLEDGE TRANSFER NETWORK LIMITED
United Kingdom
EU contribution
€ 42 413,52
Address
52 Upper Street Suite 218 Business Design Centre Islington
N1 0QH London
Activity type
Other
Administrative Contact
Catherine Callow