CORDIS
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CORDIS

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Developing a validated technology platform for the application of oxygen dependent enzymes in synthesis and transformation of alcohols

Project information

Grant agreement ID: 613849

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 7 412 764

  • EU contribution

    € 5 247 567

Coordinated by:

THE UNIVERSITY OF MANCHESTER

United Kingdom

Objective

Currently the aerobic bio-catalytic oxidation reaction is the one that would have the biggest impact on the future uptake of industrial biotechnology in Europe. Chemical oxidation is both hazardous and has high environment impacts. Many oxidative bio-catalytic reactions and transformations have been identified in academic laboratories but only a very small number have been applied by industry to oxidize non-natural substrates.
Hence biocatalysis for oxidative chemical manufacture processes can deliver a major advantage to the European chemical-using industries and the environment. In this project we intend to develop the tools for implementation of bio-oxidation to synthesize and oxidize alcohols.
Cytochrome P450 enzymes will be investigated for hydroxylation of fatty acid derivatives and terpenes which have potential to be used in biopolymers and fragrance chemicals respectively form one line of investigation. The second is the selective oxidation of primary alcohols to give products with added value in their own right and as intermediates towards other valuable products.
To support the implementation culture collections and literature reported DNA sequences will be used to identify diverse enzymes with predicted oxidase activities, which will be used as starting point for an enzyme improvement program. Then fermentation and enzyme formulation techniques will improve reaction performance to a level where useful quantities of target products can be produced for evaluation by industrial partners, and engineering techniques will analyse and implement reactor configurations that will further improve this technology platform to enable this technology to be introduced as a routine technology in the IB industry and support the European KBBE.
Further a dynamic public engagement and dissemination program will be used to promote the project, IB and the FP7 program within the science community and the public, especially schoolchildren, to create extra value for the funders.

Coordinator

THE UNIVERSITY OF MANCHESTER

Address

Oxford Road
M13 9pl Manchester

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 092 286

Administrative Contact

Liz Fay (Ms.)

Participants (11)

UNIVERSITAET STUTTGART

Germany

EU Contribution

€ 719 520

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 797 674,75

BICT SRL

Italy

EU Contribution

€ 356 311

CLEA TECHNOLOGIES BV

Netherlands

EU Contribution

€ 313 348,50

PROZOMIX LIMITED

United Kingdom

EU Contribution

€ 440 029

C-TECH INNOVATION LIMITED

United Kingdom

EU Contribution

€ 416 229,75

BASF SE

Germany

EU Contribution

€ 253 751

BIO-PRODICT BV

Netherlands

EU Contribution

€ 380 241

FIRMENICH SA

Switzerland

EU Contribution

€ 430 500

CHEMISTRY INNOVATION LIMITED

United Kingdom

EU Contribution

€ 5 262,48

KNOWLEDGE TRANSFER NETWORK LIMITED

United Kingdom

EU Contribution

€ 42 413,52

Project information

Grant agreement ID: 613849

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 7 412 764

  • EU contribution

    € 5 247 567

Coordinated by:

THE UNIVERSITY OF MANCHESTER

United Kingdom

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