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A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients

Objective

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omics”-based approaches, has revealed that cancer must be considered a heterogeneous disease. Historically, “one-size-fits-all” approaches have been standard practice in CRC treatment, but with the increased understanding of the molecular/genetic heterogeneity of CRC, it is clear that novel treatments must be developed and tested in selected subgroups to maximize the benefit of these new developments. MErCuRIC is a multicentre phase Ib/II clinical trial which will assess a novel therapeutic strategy (combined treatment of a MEK inhibitor PD-0325901 or MEK-162 with a MET inhibitor PF-02341066) to combat metastasis, improve survival and change current clinical practice for CRC patients with RAS mutant (MT) and RAS wild type (WT) (with aberrant c-MET) tumours. The consortium will go beyond the current state-of-the-art by (i) employing a novel treatment strategy targeting the biology of the disease and by (ii) using next generation sequencing (NGS) and ‘xenopatients’ to identify CRC patient subgroups who will maximally benefit from this novel treatment strategy.

Field of science

  • /medical and health sciences/clinical medicine/cancer/colorectal cancer

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
University Road Lanyon Building
BT7 1NN Belfast
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 415 289,88
Administrative Contact
Colleen Spence (Mrs.)

Participants (12)

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
EU contribution
€ 431 625,22
Address
Calle Nazaret 115-117
08035 Barcelona
Activity type
Research Organisations
Administrative Contact
Andrés De Kelety Alcaide (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 486 544,38
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
EU contribution
€ 430 946,28
Address
Drie Eikenstraat 655
2650 Edegem
Activity type
Research Organisations
Administrative Contact
Marc Peeters (Prof.)
VELINDRE NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 330 183,09
Address
Parc Nantgarw-charnwood Court 2
CF15 7QZ Cardiff
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Richard Adams (Dr.)
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 330 183,09
Address
Saint Stephen's Green 123
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bryan Hennessy (Dr.)
UNIVERSITE PARIS DESCARTES
France
EU contribution
€ 210 200
Address
Rue De L Ecole De Medecine 12
75270 Paris Cedex 06
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosaly Datchi (Ms.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 711 319
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alberto Bardelli (Prof.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 659 994,44
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
MULTIPLICOM NV
Belgium
EU contribution
€ 193 880,20
Address
Galileilaan 18
2845 Niel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jurgen Del-Favero (Prof.)
Masarykova univerzita
Czechia
EU contribution
€ 200 595
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarína Hanušová (Mrs.)
PINTAIL LTD
Ireland
EU contribution
€ 165 925,20
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)
BELFAST HEALTH AND SOCIAL CARE TRUST
United Kingdom
EU contribution
€ 433 308,82
Address
Lisburn Road Belfast City Hospital A Floor
BT9 7AS Belfast
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kate O'brien (Ms.)