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A Phase Ia/b study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients.

Objective

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omics”-based approaches, has revealed that cancer must be considered a heterogeneous disease. Historically, “one-size-fits-all” approaches have been standard practice in CRC treatment, but with the increased understanding of the molecular/genetic heterogeneity of CRC, it is clear that novel treatments must be developed and tested in selected subgroups to maximize the benefit of these new developments. MErCuRIC is a multicentre phase Ia/b clinical trial which will assess a novel therapeutic strategy (combined treatment of a MEK inhibitor PD-0325901 or MEK-162 with a MET inhibitor PF-02341066) to combat metastasis, improve survival and change current clinical practice for CRC patients with RAS mutant (MT) and RAS wild type (WT) (with aberrant c-MET) tumours. The consortium will go beyond the current state-of-the-art by (i) employing a novel treatment strategy targeting the biology of the disease and by (ii) using next generation sequencing (NGS) and ‘xenopatients’ to identify CRC patient subgroups who will maximally benefit from this novel treatment strategy.

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
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Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
University Road Lanyon Building
BT7 1NN Belfast
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Spence (Mrs.)
EU contribution
€ 541 289,87

Participants (12)

FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
EU contribution
€ 230 040,76
Address
Calle Nazaret 115-117
08035 Barcelona

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Activity type
Research Organisations
Administrative Contact
Andrés De Kelety Alcaide (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 019 511,61
Address
Wellington Square University Offices
OX1 2JD Oxford

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
EU contribution
€ 346 183,49
Address
Drie Eikenstraat 655
2650 Edegem

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Activity type
Research Organisations
Administrative Contact
Marc Peeters (Prof.)
VELINDRE NATIONAL HEALTH SERVICE TRUST
United Kingdom
EU contribution
€ 42 294,42
Address
Parc Nantgarw-charnwood Court 2
CF15 7QZ Cardiff

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Richard Adams (Dr.)
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
EU contribution
€ 222 459,57
Address
St Stephen's Green 123
2 Dublin

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bryan Hennessy (Dr.)
Université Paris Descartes
France
EU contribution
€ 112 471,96
Address
Rue De L'ecole De Médecine
75270 cedex 06 Paris

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosaly Datchi (Ms.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 334 134,83
Address
Via Giuseppe Verdi 8
10124 Torino

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alberto Bardelli (Prof.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 237 335,52
Address
3 Avenue Victoria
75000 Paris

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Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
MULTIPLICOM NV
Belgium
EU contribution
€ 72 050,76
Address
Galileilaan 18
2845 Niel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jurgen Del-Favero (Prof.)
Masarykova univerzita
Czechia
EU contribution
€ 60 066,32
Address
Zerotinovo Namesti 9
601 77 Brno

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarína Hanušová (Mrs.)
PINTAIL LTD
Ireland
EU contribution
€ 147 001,77
Address
Springhill Avenue 77
A94 K542 Blackrock

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)
BELFAST HEALTH AND SOCIAL CARE TRUST
United Kingdom
EU contribution
€ 93 679,60
Address
Lisburn Road Belfast City Hospital A Floor
BT9 7AS Belfast

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Kate O'brien (Ms.)