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PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES

Objective

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on target sites for which there is strong evidence of pathogenicity explain the disappointing effect of current treatments. The PROPANE STUDY aims to address these issues through a solid clinical and genetic approach employing an innovative technological platform. The main objectives are to resolve the genetic architecture of painful neuropathy achieving a stratification of high-risk neuropathic pain patients by novel biomarkers, to deepen understanding of underlying mechanisms and druggable targets and to identify new molecules tailored to potentially drug-responder patients and determine their effects in pre-clinical settings. Results will advance the field beyond the current state-of-the-art opening a window upon a validated individualized pain medicine and having an innovative impact both on patients’ care and market applications. These aims will be achieved by a complementary approach based on targeted sequencing of the 5 sodium channel genes expressed in the nociceptive pathway and identification of new targets by unbiased whole exome sequencing and transcriptome assay. Melding of these two approaches offers a close-to-optimal balance between highly-focused, challenging but clearly achievable goals (sodium channels in pain) and a broader unbiased approach that will capture and deliver other targets and approaches from our unique patient population. Our strong preliminary findings were the departure point of the PROPANE STUDY and the expected results could be translated into solutions able to benefit a large population of pain patients in terms of diagnosis and treatment.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA
Address
Via Giovanni Celoria 11
20133 Milano
Italy
Activity type
Research Organisations
EU contribution
€ 709 286
Administrative Contact
Francesca Grechi (Dr.)

Participants (8)

UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 183 453
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Laurent Louwies (Ms.)
YALE UNIVERSITY
United States
EU contribution
€ 824 676
Address
Whitney Avenue 155 Room 214
06520 8337 New Haven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jeffrey Mcguinness (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 416 069
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)
DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV
Germany
EU contribution
€ 308 407
Address
Auf M Hennekamp 65
40225 Duesseldorf
Activity type
Research Organisations
Administrative Contact
Dan Ziegler (Prof.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 340 672
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Sophie Deschaintres (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 536 806
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
CONVERGENCE PHARMACEUTICALS LIMITED
United Kingdom
EU contribution
€ 450 023
Address
High Holborn 90
WC1 6XX London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Tate (Mr.)
CFc srl
Italy
EU contribution
€ 75 697
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Mrs.)