Objectif Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on target sites for which there is strong evidence of pathogenicity explain the disappointing effect of current treatments. The PROPANE STUDY aims to address these issues through a solid clinical and genetic approach employing an innovative technological platform. The main objectives are to resolve the genetic architecture of painful neuropathy achieving a stratification of high-risk neuropathic pain patients by novel biomarkers, to deepen understanding of underlying mechanisms and druggable targets and to identify new molecules tailored to potentially drug-responder patients and determine their effects in pre-clinical settings. Results will advance the field beyond the current state-of-the-art opening a window upon a validated individualized pain medicine and having an innovative impact both on patients’ care and market applications. These aims will be achieved by a complementary approach based on targeted sequencing of the 5 sodium channel genes expressed in the nociceptive pathway and identification of new targets by unbiased whole exome sequencing and transcriptome assay. Melding of these two approaches offers a close-to-optimal balance between highly-focused, challenging but clearly achievable goals (sodium channels in pain) and a broader unbiased approach that will capture and deliver other targets and approaches from our unique patient population. Our strong preliminary findings were the departure point of the PROPANE STUDY and the expected results could be translated into solutions able to benefit a large population of pain patients in terms of diagnosis and treatment. Champ scientifique natural scienceschemical sciencesinorganic chemistryalkali metalsnatural scienceschemical sciencesorganic chemistryaliphatic compounds Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2013.2.2.1-5 - Understanding and controlling pain Appel à propositions FP7-HEALTH-2013-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Contribution de l’UE € 709 286,00 Adresse VIA GIOVANNI CELORIA 11 20133 Milano Italie Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Research Organisations Contact administratif Francesca Grechi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITEIT MAASTRICHT Pays-Bas Contribution de l’UE € 1 183 453,00 Adresse MINDERBROEDERSBERG 4 6200 MD Maastricht Voir sur la carte Région Zuid-Nederland Limburg (NL) Zuid-Limburg Type d’activité Higher or Secondary Education Establishments Contact administratif Laurent Louwies (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée YALE UNIVERSITY États-Unis Contribution de l’UE € 824 676,00 Adresse WHITNEY AVENUE 155 ROOM 214 06520 8337 New Haven Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Jeffrey Mcguinness (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée THE UNIVERSITY OF MANCHESTER Royaume-Uni Contribution de l’UE € 416 069,00 Adresse OXFORD ROAD M13 9PL Manchester Voir sur la carte Région North West (England) Greater Manchester Manchester Type d’activité Higher or Secondary Education Establishments Contact administratif Claire Faichnie (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV Allemagne Contribution de l’UE € 308 407,00 Adresse AUF M HENNEKAMP 65 40225 Duesseldorf Voir sur la carte Région Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Type d’activité Research Organisations Contact administratif Dan Ziegler (Prof.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Contribution de l’UE € 340 672,00 Adresse RUE MICHEL ANGE 3 75794 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Sophie Deschaintres (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FONDAZIONE CENTRO SAN RAFFAELE Italie Contribution de l’UE € 536 806,00 Adresse VIA OLGETTINA 60 20132 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Research Organisations Contact administratif Maria Rosa Pedrazzi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CONVERGENCE PHARMACEUTICALS LIMITED Royaume-Uni Contribution de l’UE € 450 023,00 Adresse HIGH HOLBORN 90 WC1 6XX LONDON Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Simon Tate (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL Italie Contribution de l’UE € 75 697,00 Adresse Via Giuseppe Mussi 1 20154 Milano Voir sur la carte Région Nord-Ovest Lombardia Milano Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Carla Finocchiaro (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
