Objective IMMODGEL aims to identify adverse immune reactions to dental and larynx titanium implants and to develop a novel therapeutic strategy to significantly decrease the implant and medical device failure caused by these reactions via design of an innovative immunomodulatory system. The system will be designed to be fixed to an implant via an adhesive polyelectrolyte multilayer and control the immune response by autologous, phenotype modulated macrophages encapsulated in a hydrogel. The auxiliary nature of the design allows it to be adjusted to any implant, medical device or transplant. IMMODGEL will apply complex systems immunology, epidemiology, and functional approaches to identify key adverse immune reactions caused by implants and detrimental macrophage phenotypes around titanium implants. This will be used to establish the optimal biomaterial composition and cytokine delivery system for the immunomodulatory hydrogel design to revert macrophage-induced inflammatory reactions (M1) to the optimal tolerogenic and healing reactions (M2). Long-term fixation of the desired M2 phenotype will significantly decrease the level and duration of implant-induced inflammation, and optimise healing phase. The interaction of implants and medical devices with the immune system will be modelled to develop a “Foreign Body Response on-a-chip” to predict patient’s specific responses to implant materials and modify the immunomodulatory hydrogel accordingly, as a step towards personalized implants with minimal adverse reactions. The gels will be incorporated to engineered tissues for validation. Validation of the approach will be performed in vivo in animal models. Significantly suppressed inflammatory responses and optimal tissue remodelling and healing around titanium implants is expected. The key innovation will be the development of IMMODGEL as an auxiliary system to improve the outcomes of implantation and reduce the cost of implant complication and related medical costs in Europe. Fields of science medical and health scienceshealth sciencespublic healthepidemiologynatural scienceschemical sciencesinorganic chemistrytransition metalsmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.1.3-2 - Innovative approaches to address adverse immune reactions to biomedical devices, implants and transplant tissues Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator STEINBEIS 2I GMBH EU contribution No data Address LEUSCHNERSTRASSE 43 70176 Stuttgart Germany See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mercedes Dragovits (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE STRASBOURG France EU contribution € 831 078,40 Address RUE BLAISE PASCAL 4 67081 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Higher or Secondary Education Establishments Administrative Contact Sandrine Schott-Carrière (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Germany EU contribution € 969 461,00 Address SEMINARSTRASSE 2 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Julia Kzhyshkowska (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 675 914,40 Address University Park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Administrative Contact Jill Harris (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BRIGHAM INC United States EU contribution € 581 269,50 Address FRANCIS STREET 75 02115 BOSTON MA See on map Activity type Research Organisations Administrative Contact Ali Khademhosseini (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROTIP MEDICAL France EU contribution € 1 109 353,20 Address 8 PLACE DE L'HOPITAL 67000 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nihal Engin Vrana (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROTOBIOS OU Estonia EU contribution € 653 464,50 Address MAEALUSE 4 12618 Tallinn See on map Region Eesti Eesti Põhja-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kaia Palm (Dr.) Links Contact the organisation Opens in new window Total cost No data CONTIPRO BIOTECH SRO Participation ended Czechia EU contribution € 306 231,50 Address DOLNI DOBROUC 401 56102 DOLNI DOBROUC See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Leona Markova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONTIPRO AS Czechia EU contribution € 219 411,60 Address DOLNI DOBROUC 401 561 02 Dolni Dobrouc See on map Region Česko Severovýchod Pardubický kraj Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Leona Markova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STEINBEIS INNOVATION GGMBH Participation ended Germany EU contribution € 505 132,00 Address ADORNOSTRASSE 8 70599 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Research Organisations Administrative Contact Mercedes Laura Dragovits (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data