Objectif The creation of new molecular entities and subsequent exploitation of their properties is central to a broad spectrum of research disciplines from medicine to materials. Most –if not all- of the efforts of organic chemists were directed to the development of creative strategies to built carbon-carbon and carbon-heteroatom bonds in a predictable and efficient manner. But is the creation of new bonds the only approach that organic chemistry should follow? Could we design the synthesis of challenging molecular skeleton no more through the construction of carbon-carbon bonds but rather through selective cleavage of carbon-carbon bonds (C-C bond activation)? The goal of this work is to develop powerful synthetic approaches for the selective C-C bond activation and demonstrate that it has the potential to be a general principle in organic synthesis for the regio-, diastereo- and even enantiomerically enriched preparation of adducts despite that C-C single bonds belong among the least reactive functional groups in chemistry. The realization of this synthetic potential requires the ability to functionalize selectively one C-C bond in compounds containing many such bonds and an array of functional groups. This site selective C-C bond activation is one of the greatest challenges that must be met to be used widely in complex-molecular synthesis. To emphasize the practicality of C-C bond activation, we will prepare in a single-pot operation challenging molecular framework possessing various stereogenic centers from very simple starting materials through selective C-C bond activation. Ideally, alkenes will be in-situ transformed into alkanes that will subsequently undergo the C-C activation even in the presence of functional group. This work will lead to ground-breaking advances when non-strained cycloalkanes (cyclopentane, cyclohexane) will undergo this smooth C-C bond activation with friendly and non toxic organometallic species. Champ scientifique natural scienceschemical sciencesorganic chemistry Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Appel à propositions ERC-2013-ADG Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Contribution de l’UE € 2 367 495,00 Adresse SENATE BUILDING TECHNION CITY 32000 Haifa Israël Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Ilan Marek (Prof.) Contact administratif Mark Davison (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israël Contribution de l’UE € 2 367 495,00 Adresse SENATE BUILDING TECHNION CITY 32000 Haifa Voir sur la carte Type d’activité Higher or Secondary Education Establishments Chercheur principal Ilan Marek (Prof.) Contact administratif Mark Davison (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée