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Training in neurodegeneration, therapeutics intervention and neurorepair

Objective

Dopamine neurons play a central role in major illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementia. A multidisciplinary approach must be taken by European researchers to discover the molecular basis of dopamine neurodegeneration and how new technologies will lead to repair and regeneration of neuronal systems in the brain. The TINTIN proposal describes how early stage researchers (ESRs) and experienced researchers (ERs) will undertake advanced research training projects on metabolism and autophagy in neurons, induced pluripotent stem cells and neurorepair systems. Parallel research projects will involve computational modelling of metabolism in the dopamine neuron and the in silico design of novel therapeutics that are selectively transported into the dopamine neuron. This fundamental training and research will be merged with new cutting edge glycan based biomarker technologies, drug simulation and computational/mathematical models of dopaminergic neurons. TINTIN will train young researchers by merging key research groups in 7 Universities and 8 industry/SME partners from Western Europe (Ireland, UK) across central and Southern Europe (Denmark, Germany, Austria, Italy, Spain) and Eastern Europe (Turkey). The secondments of ESRs and ERs into and out of 8 commercial partners in the area of glycan discovery and drug design will ensure that researchers receive intensive training in emerging research areas in neurotherapeutic development as well as key information in how to commercialize such innovation and discovery. The breadth of the aims, techniques and knowledge of TINTIN, the academic basis, the integrating of ESRs and ERs into industry, the potential for transfer to the European pharmaceutical industry, and enrichment of scientific training across Europe all fit the ITN model.

Call for proposal

FP7-PEOPLE-2013-ITN
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Coordinator

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Address
College Green Trinity College
D02 CX56 Dublin 2
Ireland

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Deirdre Savage (Ms.)
EU contribution
€ 1 267 752,02

Participants (7)

UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 541 208,80
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms.)
UNIVERSIDAD DE SALAMANCA
Spain
EU contribution
€ 475 363,24
Address
Calle Patio De Escuelas 1
37008 Salamanca

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
María De Los Ángeles Serrano García (Prof.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 301 556,64
Address
Oxford Road
M13 9PL Manchester

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Dr.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 227 568,88
Address
Square J 5
68159 Mannheim

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Simone Fuchs (Ms.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 503 675,92
Address
Via Banchi Di Sotto 55
53100 Siena

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Massimo Valoti (Prof.)
KADIR HAS UNIVERSITESI
Turkey
EU contribution
€ 249 795,04
Address
Kadir Has Avenue
34230 Istanbul

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kemal Yelekci (Prof.)
NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING LIMITED
Ireland
EU contribution
€ 250 314,46
Address
Fosters Avenue Mount Merrion
4 Blackrock Dublin

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Activity type
Research Organisations
Administrative Contact
Pauline Rudd (Prof.)