CORDIS
EU research results

CORDIS

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Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies

Objective

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD.
To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 25 clinical sites from 16 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Address

Chariteplatz 1
10117 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 538 595

Administrative Contact

Adriane Napp (Ms.)

Participants (34)

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MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 154 304

UNIVERSITAIR ZIEKENHUIS ANTWERPEN

Belgium

FAKULTNI NEMOCNICE V MOTOLE

Czechia

EU Contribution

€ 113 220

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 222 126

KLINIKEN DES LANDKREISES GOPPINGEN GGMBH

Germany

EU Contribution

€ 130 696

UNIVERSITAET LEIPZIG

Germany

EU Contribution

€ 130 696

SEMMELWEIS EGYETEM

Hungary

EU Contribution

€ 127 320

SOUTH EASTERN HEALTH AND SOCIAL CARE TRUST NHS

United Kingdom

EU Contribution

€ 164 310

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 165 480

UNIVERSITA DEGLI STUDI DI CAGLIARI

Italy

EU Contribution

€ 97 920

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 101 032

PAULA STRADINA KLINISKA UNIVERSITATES SLIMNICA

Latvia

EU Contribution

€ 256 024

LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS

Lithuania

EU Contribution

€ 106 960

WOJEWODZKI SZPITAL SPECJALISTYCZNY WE WROCLAWIU

Poland

EU Contribution

€ 76 172

CENTRO HOSPITALAR DE VILA NOVA DE GAIA/ESPINHO EPE

Portugal

EU Contribution

€ 113 280

CARDIO MED SRL

Romania

EU Contribution

€ 97 005

INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE

Serbia

EU Contribution

€ 64 260

INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 147 340

OSTERGOTLANDS LAN

Sweden

KANTONSSPITAL ST. GALLEN

Switzerland

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 91 000

AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 132 160

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 151 000

FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS

Spain

EU Contribution

€ 228 600

CESKE VYSOKE UCENI TECHNICKE V PRAZE

Czechia

EU Contribution

€ 24 600

Universitätsklinikum Jena

Germany

EU Contribution

€ 199 000

VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA

Finland

EU Contribution

€ 80 480

INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

Poland

EU Contribution

€ 29 955

UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE DIN TARGU MURES

Romania

EU Contribution

€ 18 520

FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE

Serbia

EU Contribution

€ 38 960

Servicio Vasco de Salud Osakidetza

Spain

EU Contribution

€ 46 000

ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK

France

EU Contribution

€ 113 000

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 39 980

Project information

Grant agreement ID: 603266

Status

Closed project

  • Start date

    1 February 2014

  • End date

    31 January 2019

Funded under:

FP7-HEALTH

  • Overall budget:

    € 7 697 560

  • EU contribution

    € 5 999 995

Coordinated by:

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany