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NanoBioEngineering of BioInspired BioPolymers

NanoBioEngineering of BioInspired BioPolymers

Objective

The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising biopolymers, with excellent physico-chemical and material properties, and a wide range of biological functionalities, but their economic potential is far from being exploited due to i) problems with reproducibility of biological activities as today’s chitosans are rather poorly defined mixtures, and ii) the threat of allergen contamination from their typical animal origin. The Nano3Bio project will overcome these hurdles to market entry and penetration by producing in vitro and in vivo defined oligo- and polymers with controlled, tailor-made DP, DA, and PA. Genes for chitin synthases, chitin deacetylases, and transglycosylating chitinases/chitosanases will be mined from different (meta)genomic sources and heterologously expressed, the recombinant enzymes characterized and optimized by protein engineering through rational design and molecular evolution, e.g. targeting engineered glycosynthases. These enzymes and genes will be used for in vitro and in vivo biosynthesis in microbial and microalgal systems, focusing on bacteria and diatoms. The bioinspired chitosans will be formulated into biomineralised hydrogels, nanoparticles, nanoscaffolds, etc., to impart novel properties, including by surface nano-imprinting, and will be bench-marked against their conventional counterparts in a variety of cell based assays and routine industrial tests for e.g. cosmetics and pharma markets. The process will be accompanied by comprehensive life cycle assessments including thorough legal landscaping, and by dissemination activities targeted to the scientific community and the general public.
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Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Address

Schlossplatz 2
48149 MÜNster

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 654 200

Administrative Contact

Bruno Moerschbacher (Prof.)

Administrative Contact

Ingo Niendorf (Mr.)

Participants (21)

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UNIVERSITEIT GENT

Belgium

EU Contribution

€ 1 280 150

INSTITUT QUIMIC DE SARRIA

Spain

EU Contribution

€ 480 938

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 783 810

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 389 480

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 491 111

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

EU Contribution

€ 410 539

UNIVERSITY OF HYDERABAD

India

EU Contribution

€ 139 600

GENEART AG

Germany

EU Contribution

€ 373 200

GILLET CHITOSAN EURL

France

EU Contribution

€ 137 040

COSPHATEC GMBH

Germany

EU Contribution

€ 200 824

BIO BASE EUROPE PILOT PLANT VZW

Belgium

EU Contribution

€ 377 600

GREENALTECH SL

Spain

EU Contribution

€ 435 600

GREENDELTA GMBH

Germany

EU Contribution

€ 87 120

2.-O LCA CONSULTANTS APS

Denmark

EU Contribution

€ 114 580

ARTES BIOTECHNOLOGY GmbH

Germany

EU Contribution

€ 202 368

LYON INGENIERIE PROJETS

France

EU Contribution

€ 384 000

PETRA TEWES-SCHWARZER - CARE SENSE CONSULTING

Germany

EU Contribution

€ 76 100

BEEMO GmbH

Germany

EU Contribution

€ 399 220

HEPPE MEDICAL CHITOSAN GMBH

Germany

EU Contribution

€ 213 644

ENANTIA SL

Spain

EU Contribution

€ 282 600

PERSEUS BVBA

Belgium

EU Contribution

€ 75 600

Project information

Grant agreement ID: 613931

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2017

Funded under:

FP7-KBBE

  • Overall budget:

    € 11 695 705,20

  • EU contribution

    € 8 989 324

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

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