Objectif The maintenance of the skeleton is tightly coupled with balanced bone formation and resorption processes that are mediated by osteoblasts and osteoclasts, respectively. Loss of this balance results in skeletal pathologies representing some of the most significant public health threats faced by the growing and ageing population. Tissue engineering investigates various health aspects such as drug development, fundamental research and regenerative medicine. State-of-the-art approaches are lacking to mimic one essential functional property of bone: to adapt its 3D morphology according to imposed mechanical loads. As most drugs for skeletal diseases act on this anabolic-catabolic balance, an engineered system serving as a human in vitro model for drug discovery/testing needs to be able to mimic this process. This proposal aims at combining real-time monitoring of mineralized extracellular matrix with bone tissue engineering culture standards in advanced bioreactors and will design a reliable 3D in vitro model system to mimic load induced remodeling of tissue-engineered human bone. The following particulars will be systematically addressed: i) Establishment of a co-culture of human bone-forming cells and human bone resorbing cells capable of mimicking bone remodeling; ii) Real-time monitoring platform in 3D in order to take the temporo-spatial development of the tissue into account and to allow specific adapted and controlled interventions depending on the actual environmental situation; iii) Quantitative simulation of morphological bone adaptation induced by mechanical load. The proposed research activity will have important implications in fields ranging from pharmacology and biotechnology to biomechanics and medicine. It will result in a ground-breaking platform that could be applied to screen initial bone drug effects and will improve our fundamental understanding of structure-function relationships in normal and diseased bone conditions. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencespublic healthepidemiologyepidemics preventionmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesbiophysics Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE8 - ERC Starting Grant - Products and process engineering Appel à propositions ERC-2013-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil TECHNISCHE UNIVERSITEIT EINDHOVEN Contribution de l’UE € 1 496 859,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Pays-Bas Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Contact administratif J.M.R. Debeij (Mr.) Chercheur principal Sandra Hofmann Boss (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TECHNISCHE UNIVERSITEIT EINDHOVEN Pays-Bas Contribution de l’UE € 1 496 859,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Contact administratif J.M.R. Debeij (Mr.) Chercheur principal Sandra Hofmann Boss (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée