Obiettivo Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progenitor. The project pulls together stem cell experts, genetic engineers, developmental biologists, cell therapy pioneers, bioengineers and specialist SMEs in a cross-disciplinary collaborative effort. Close-working between partners will be maximised through specialist workshops, laboratory exchange schemes, regular workpackage meetings, and joint Deliverables. The concept underlying PluriMes is that refined control of early fate decisions to produce correctly specified progenitors will be obtained through confronting developmental principles with engineering logic. We aim to define ground states and resolve issues of hierarchy, heterogeneity and stability in order to provide standardised PSC and mesodermal progenitor cell populations. A toolbox of fluorescent reporters will be developed for live cell tracking. Cutting edge bioengineering approaches will be implemented for dynamic topological administration of morphogens, matrices, small molecule modulators and siRNAs in 2D and 3D contexts. Through SME involvement, culture systems will be optimised for specification and subsequent stable expansion of mesodermal progenitors. The capacity of PSC-derived mesodermal cells for maturation into skeletal muscle, bone and cartilage will be tested in vitro and in vivo using lineage reporters. Potency will then be evaluated in pre-clinical disease models. Scale up protocols will be implemented in partnership with SMEs using the latest bioreactor technologies. Finally, GMP compliance and validated applicability to clinical grade stem cells will underpin future cell therapy propositions. Campo scientifico engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologycells technologiesstem cells Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.1.4-1 - Controlling differentiation and proliferation in human stem cells intended for therapeutic use Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contributo UE € 1 593 172,26 Indirizzo TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Regno Unito Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Renata Schaeffer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY COLLEGE LONDON Contributo UE € 919 049,20 Indirizzo GOWER STREET WC1E 6BT LONDON Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Malgorzata Kielbasa (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italia Contributo UE € 434 240,00 Indirizzo Piazzale Aldo Moro 5 00185 Roma Mostra sulla mappa Regione Centro (IT) Lazio Roma Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maria Letizia Savini (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato NCARDIA BV Paesi Bassi Contributo UE € 150 000,00 Indirizzo GALLILEIWEG 8 2333 BD Leiden Mostra sulla mappa Regione West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Stefan Braam (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato STEMCELL TECHNOLOGIES SARL Partecipazione conclusa Francia Contributo UE € 21 327,74 Indirizzo MINIPAR POLYTEC RUE DES BERGES 40 38000 GRENOBLE Mostra sulla mappa Regione Auvergne-Rhône-Alpes Rhône-Alpes Isère Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Marie-Claude Genevay (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato TECHNISCHE UNIVERSITAET DRESDEN Germania Contributo UE € 441 340,00 Indirizzo HELMHOLTZSTRASSE 10 01069 Dresden Mostra sulla mappa Regione Sachsen Dresden Dresden, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Sven Kreigenfeld (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF SHEFFIELD Regno Unito Contributo UE € 399 762,80 Indirizzo FIRTH COURT WESTERN BANK S10 2TN Sheffield Mostra sulla mappa Regione Yorkshire and the Humber South Yorkshire Sheffield Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Joanne Watson (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ACADEMISCH ZIEKENHUIS LEIDEN Paesi Bassi Contributo UE € 425 765,60 Indirizzo ALBINUSDREEF 2 2333 ZA Leiden Mostra sulla mappa Regione West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Liesbeth Dorama (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Svizzera Contributo UE € 402 791,60 Indirizzo BATIMENT CE 3316 STATION 1 1015 Lausanne Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Matthias Lutolf (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Francia Contributo UE € 399 940,00 Indirizzo Rue Laurent Fries 1 67404 Illkirch Graffenstaden Mostra sulla mappa Regione Grand Est Alsace Bas-Rhin Tipo di attività Research Organisations Contatto amministrativo Steve Brooks (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato STEMCELL TECHNOLOGIES UK LTD Regno Unito Contributo UE € 734 072,00 Indirizzo BUILDING 7100 CAMBRIDGDE RESEARCH PARK BEACH DRIVE WATERBEACH CB25 9TL Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Frederic Bouffechoux (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato THE UNIVERSITY OF MANCHESTER Regno Unito Contributo UE € 78 538,80 Indirizzo OXFORD ROAD M13 9PL Manchester Mostra sulla mappa Regione North West (England) Greater Manchester Manchester Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Claire Faichnie (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato