Obiettivo The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum antibiotics. For the treatment a nanotherapeutic based inhalable antibiotic will be developed. The therapeutic nanosystem will be based on a nanocarrier combined with an antimicrobial peptide. 3 different types of NCs will be tested with 2 AMPs to be able to obtain a novel effective inhalable antimicrobial NS. Nanotherapeutics offers many advantages in pulmonary drug-delivery, due to the huge surface area available in the lungs and their potential to achieve uniform distribution of drug dose among the alveoli. To improve this delivery to the lungs an aerosol system will also be developed. Due to the characteristics related to pulmonary delivery of NCs, topical and systemic bioavailabilities are envisaged. A diagnostic kit will be generated to monitor the efficacy and efficiency of the therapy. Once this treatment is proved to be effective, it could then be applied to any Gram-negative lung bacterial infection.The number of antibiotic resistant bacteria strains is increasing rapidly, new types of therapy are urgently required to avoid the use of standard antibiotics. Gram-negative bacteria that cause pneumonia are one of the main sources of nosocomial infections, mainly in people with a weakened immune system. Apart from pneumonia they can cause bacteremia and other infections. Early detection of the infection source combined with the development of appropriate and effective NSs to treat multi-drug resistant (MDR) bacteria caused infections will definitely radically improve the healing process of patients and avoid complications for people in hospital. Campo scientifico medical and health sciencesclinical medicinepneumologynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programma(i) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Argomento(i) NMP.2013.1.2-2 - Nanotherapeutics to treat bacterial infectious diseases Invito a presentare proposte FP7-NMP-2013-LARGE-7 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-IP - Large-scale integrating project Coordinatore FUNDACION CIDETEC Contributo UE € 896 660,00 Indirizzo PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON 20014 San Sebastian Spagna Mostra sulla mappa Regione Noreste País Vasco Gipuzkoa Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ADENIUM BIOTECH APS Danimarca Contributo UE € 416 300,00 Indirizzo OLE MAALOESVEJ 3 2200 KOBENHAVN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Spagna Contributo UE € 555 990,80 Indirizzo PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 20009 San Sebastian Mostra sulla mappa Regione Noreste País Vasco Gipuzkoa Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Paesi Bassi Contributo UE € 975 861,20 Indirizzo DR MOLEWATERPLEIN 40 3015 GD Rotterdam Mostra sulla mappa Regione West-Nederland Zuid-Holland Groot-Rijnmond Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Germania Contributo UE € 332 340,00 Indirizzo HEINRICH-HERTZ-ALLEE 1 66386 St Ingbert Mostra sulla mappa Regione Saarland Saarland Saarpfalz-Kreis Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germania Contributo UE € 511 251,25 Indirizzo HANSASTRASSE 27C 80686 Munchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato INGENIATRICS TECNOLOGIAS SL Spagna Contributo UE € 454 658,00 Indirizzo CALLE CAMINO MOZARABE 41 PARQUE INDUSTRIAL PARQUE PLATA CAMAS 41900 SEVILLA Mostra sulla mappa Regione Sur Andalucía Sevilla Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato PATHOFINDER BV Paesi Bassi Contributo UE € 497 681,60 Indirizzo RANDWYCKSINGEL 45 6229 EG MAASTRICHT Mostra sulla mappa Regione Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato SETLANCE SRL Italia Contributo UE € 341 902,40 Indirizzo VIA FIORENTINA 1 53100 Siena Mostra sulla mappa Regione Centro (IT) Toscana Siena Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UMAPS COMMUNICATION SARL Francia Contributo UE € 183 520,00 Indirizzo AVENUE DE LA RESISTANCE 104 112 93100 MONTREUIL Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITEIT UTRECHT Paesi Bassi Contributo UE € 516 185,75 Indirizzo HEIDELBERGLAAN 8 3584 CS Utrecht Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
