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Advanced Materials for Cardiac Regeneration (AMCARE)

Project information

Grant agreement ID: 604531

Status

Closed project

  • Start date

    1 November 2013

  • End date

    31 October 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 8 718 194,20

  • EU contribution

    € 6 795 349

Coordinated by:

ROYAL COLLEGE OF SURGEONS IN IRELAND

Ireland

Objective

The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomaterial delivery systems for CPCs will be investigated in the AMCARE work programme including HA-based patches (CardioPatch) and HA-hydrogels (CardioGel). We also propose to develop two prototypes of new surgical devices [C-CathGel and SPREDS] that will ensure a minimally invasive delivery and fixation approach that is safe and effective for each therapeutic. The combinations of advanced material carriers and surgical devices will be assessed in a large animal model of acute-MI to best align our approach to clinical translation. The novel formulations and delivery methods will help post-MI patients in restoring cardiac function by targeting for repair the underlying myocardium damage, and could potentially decrease morbidity and mortality in the future. These goals will be achieved by integrating numerous areas of materials science and stem cell biology as well as leaders in the field of medical devices, biomaterials and cardiovascular regeneration. We thus aim to improve long-term healthcare of EU citizens by offering a revolutionary therapeutic modality for the treatment of acute-MI.

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND

Address

Saint Stephen'S Green 123
2 Dublin

Ireland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 286 514

Participants (11)

CONTIPRO BIOTECH SRO

Czechia

EU Contribution

€ 210 446,30

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 803 806

CONTIPRO AS

Czechia

EU Contribution

€ 246 433,70

INNOVA SRL

Italy

EU Contribution

€ 398 927

ADJUCOR GMBH

Germany

EU Contribution

€ 795 960

CELYAD

Belgium

EU Contribution

€ 1 240 734

EXPLORA SRL

Italy

EU Contribution

€ 744 400

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 733 429

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

EU Contribution

€ 107 831

BOSTON SCIENTIFIC IRELAND LIMITED

Ireland

BOSTON SCIENTIFIC LIMITED

Ireland

EU Contribution

€ 226 868

Project information

Grant agreement ID: 604531

Status

Closed project

  • Start date

    1 November 2013

  • End date

    31 October 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 8 718 194,20

  • EU contribution

    € 6 795 349

Coordinated by:

ROYAL COLLEGE OF SURGEONS IN IRELAND

Ireland

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