Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokine-based therapies

Ziel

Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. In this project we will reinvestigate key aspects of cytokine receptor activation and signaling using novel insights and techniques recently developed in our laboratory. This will include the AcTakine concept for cell-specific targeting of cytokine activity, and applications of our MAPPIT, KISS and Virotrap toolboxes to systematically map protein interactions involved in cytokine signaling. We expect to obtain important new insights, both in fundamental and in applied medical sciences.

Wissenschaftliches Gebiet

Finanzierungsplan

ERC-AG - ERC Advanced Grant

Gastgebende Einrichtung

VIB VZW

EU-Beitrag

€ 2 487 728,40

Adresse

SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgien

Region

Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent

Aktivitätstyp

Research Organisations

Hauptforscher

Jan Tavernier (Prof.)

Kontakt Verwaltung

Rik Audenaert (Mr.)

Links

Die Organisation kontaktieren Website

Gesamtkosten

Keine Daten

Begünstigte (1)