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Health and Environment-wide Associations based on Large population Surveys

Health and Environment-wide Associations based on Large population Surveys

Objective

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools that support efficiently exposome studies. The general objective of HEALS is the refinement of an integrated methodology and the application of the corresponding analytical and computational tools for performing environment-wide association studies in support of EU-wide environment and health assessments. The exposome represents the totality of exposures from conception onwards, simultaneously identifying, characterizing and quantifying the exogenous and endogenous exposures and modifiable risk factors that predispose to and predict diseases throughout a person’s life span. The HEALS approach brings together and organizes environmental, socio-economic, exposure, biomarker and health effect data; in addition, it includes all the procedures and computational sequences necessary for applying advanced bioinformatics coupling thus effective data mining, biological and exposure modeling so as to ensure that environmental exposure-health associations are studied comprehensively. The overall approach will be verified and refined in a series of population studies across Europe including twin cohorts, tackling different levels of environmental exposure, age windows of exposure, and socio-economic and genetic variability. The HEALS approach will be applied in a pilot environment and health examination survey of children including singletons and sets of twins with matched singletons (each twins pair having also a matched singleton) covering ten EU Member States (the EXHES Study). The lessons learned will be translated into scientific advice towards the development of protocols and guidelines for the setting up of a larger European environment and health examination survey.
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Coordinator

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

Address

Place Jussieu 4
75252 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 116 061,11

Administrative Contact

Isabella Annesi-Maesano (Dr.)

Participants (35)

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TEKNOLOGIAN TUTKIMUSKESKUS VTT

Finland

EU Contribution

€ 424 694,10

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Greece

EU Contribution

€ 994 803

INSTITUTE OF OCCUPATIONAL MEDICINE

United Kingdom

EU Contribution

€ 458 239,30

UNIVERSITAET STUTTGART

Germany

EU Contribution

€ 477 656

INSTITUT JOZEF STEFAN

Slovenia

EU Contribution

€ 490 776,20

UNIVERSITE PARIS DESCARTES

France

EU Contribution

€ 522 296,20

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 284 231,47

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 580 719,20

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 404 306

INSTYTUT MEDYCYNY PRACY IMIENIA PROF. DRA MED. JERZEGO NOFERA W LODZI

Poland

EU Contribution

€ 325 994

Teknologian tutkimuskeskus VTT Oy

Finland

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 275 576,38

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

EU Contribution

€ 638 669,80

THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

United Kingdom

EU Contribution

€ 342 021,80

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 450 437,40

PANEPISTIMIO DYTIKIS MAKEDONIAS

Greece

EU Contribution

€ 317 862,50

FUNDACIO PARC CIENTIFIC DE BARCELONA

Spain

EU Contribution

€ 274 016,70

INSTITUTO DE ENGENHARIA MECANICA

Portugal

EU Contribution

€ 51 262,94

OIKON DOO INSTITUT ZA PRIMIJENJENU EKOLOGIJU

Croatia

EU Contribution

€ 133 549,27

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 285 500,70

UNIVERSIDADE DO PORTO

Portugal

EU Contribution

€ 336 698,80

"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Greece

EU Contribution

€ 447 565,40

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 312 893,30

KLINIKUM DER UNIVERSITAET REGENSBURG

Germany

EU Contribution

€ 248 950

GENOMIC INVESTMENTS BV

Netherlands

EU Contribution

€ 198 333

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 286 263,60

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 61 668

SYDDANSK UNIVERSITET

Denmark

EU Contribution

€ 61 668

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

EU Contribution

€ 75 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 61 668

INEGI - INSTITUTO DE CIENCIA E INOVACAO EM ENGENHARIA MECANICA E ENGENHARIA INDUSTRIAL

Portugal

EU Contribution

€ 207 590,55

FERA SCIENCE LIMITED

United Kingdom

ZELENA INFRASTRUKTURA DRUSTVO S OGRANICENOM ODGOVORNOSCU ZA ZASTITU OKOLISA I PROSTORNO UREDENJE

Croatia

EU Contribution

€ 192 233,13

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 175 277,93

GenomeScan B.V.

Netherlands

Project information

Grant agreement ID: 603946

Status

Closed project

  • Start date

    1 October 2013

  • End date

    30 September 2018

Funded under:

FP7-ENVIRONMENT

  • Overall budget:

    € 14 982 032,56

  • EU contribution

    € 11 514 483,78

Coordinated by:

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France